RAP2B - RAP2B, member of RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5912

About RAP2B

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:153,162,226-153,170,627 (from NCBI)

This gene has 1 transcript (splice variant), 184 orthologues and 35 paralogues.

Summary

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical Ras proteins and have numerous structural features in common. The most striking difference between the RAP and Ras proteins resides in their 61st amino acid: glutamine in Ras is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

RAP2B Products (1)

mRNA	Protein	Name
NM_002886.4	NP_002877.2	ras-related protein Rap-2b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	16213650	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	16213650	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	23885123	GOA
NOT involved in microvillus assembly	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in platelet activation	IDA IDA: Inferred from direct assay	18582561	GOA
involved in platelet aggregation	IDA IDA: Inferred from direct assay	18582561	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	23885123	GOA
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	23885123	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18582561	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	16540189	GOA
located in membrane	IMP IMP: Inferred from mutant phenotype	18582561	GOA
located in membrane raft	IMP IMP: Inferred from mutant phenotype	18582561	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16213650	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP2B Protein Structure

Ras

0
100
183 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rap-2b	small GTP binding protein

RAP2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAP2B	P61225	CAMK2B	Homo sapiens	Q13554	Y2H Array	25416956
Intra	RAP2B	P61225	CAMK2B	Homo sapiens	Q13554-3	Y2H Prey Pooling	32296183
Intra	RAP2B	P61225	CAMK2B	Homo sapiens	Q13554-3	Y2H Array	32296183
Intra	RAP2B	P61225	CAMK2B	Homo sapiens	Q13554-3	Validated Y2H	32296183
Intra	RAP2B	P61225	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Prey Pooling	32296183
Intra	RAP2B	P61225	RUNDC3A	Homo sapiens	Q59EK9-3	Validated Y2H	32296183
Intra	RAP2B	P61225	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Array	32296183
Intra	RAP2B	P61225	RAP1GDS1	Homo sapiens	P52306-5	Y2H Prey Pooling	32296183
Intra	RAP2B	P61225	RAP1GDS1	Homo sapiens	P52306-5	Y2H Array	32296183
Intra	RAP2B	P61225	RASSF5	Homo sapiens	Q8WWW0	Validated Y2H	25416956
Intra	RAP2B	P61225	RASSF5	Homo sapiens	Q8WWW0	Y2H Prey Pooling	25416956
Intra	RAP2B	P61225	RUNDC3A	Homo sapiens	Q59EK9	Y2H Prey Pooling	25416956
Intra	RAP2B	P61225	RUNDC3A	Homo sapiens	Q59EK9	Y2H Array	25416956
Intra	RAP2B	P61225	RUNDC3A	Homo sapiens	Q59EK9	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Smith-Mccort Dysplasia 1	Smith-Mccort Dysplasia SMC1 Smc Smith Mccort Dysplasia Smith-Mccort Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11658	RAP2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAP2B	VGNC	VGNC:33720
Felis catus	RAP2B	VGNC	VGNC:69238
Macaca mulatta	RAP2B	VGNC	VGNC:76660
Mus musculus	RAP2B	MGD	MGI:1921262
Canis familiaris	RAP2B	VGNC	VGNC:52900
Rattus norvegicus	RAP2B	RGD	RGD:620591
Others	RAP2B	NCBI