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RASSF5 - Ras association domain family member 5 Gene

Also Known as RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83593

About RASSF5

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,507,531-206,589,448 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 5 paralogues. Broad expression in bone marrow (RPKM 44.1), lymph node (RPKM 34.6) and 20 other tissues.

Summary

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several Other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RASSF5 Products (3)

mRNA	Protein	Name
NM_182663.4	NP_872604.1	ras association domain-containing protein 5 isoform A
NM_182664.4	NP_872605.1	ras association domain-containing protein 5 isoform B
NM_182665.4	NP_872606.1	ras association domain-containing protein 5 isoform C

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17517604	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9488663	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASSF5 Protein Structure

C1_1

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
ras association domain-containing protein 5	Rap1-binding protein

RASSF5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RASSF5	Q8WWW0	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	a8k940_human	Homo sapiens	A8K940	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	a8k940_human	Homo sapiens	A8K940	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	VPS28	Homo sapiens	Q548N1	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	RASSF5	Q8WWW0	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	BTRC	Homo sapiens	Q9Y297	Y2H Array	31515488
Intra	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Y2H Array	31515488
Intra	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Y2H	25502805
Intra	RASSF5	Q8WWW0	HRAS	Homo sapiens	P01112	Anti Bait CoIP	9488663
Intra	RASSF5	Q8WWW0	HRAS	Homo sapiens	P01112	Anti Tag CoIP	18596699
Intra	RASSF5	Q8WWW0	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	CoIP	15109305
Intra	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	Anti Tag CoIP	20562859
Intra	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24366813
Intra	RASSF5	Q8WWW0	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	RASSF5	Q8WWW0	MYLIP	Homo sapiens	Q8WY64	Y2H Array	31515488
Intra	RASSF5	Q8WWW0	MYLIP	Homo sapiens	Q8WY64	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	RASSF5	Q8WWW0	RABIF	Homo sapiens	P47224	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	RABIF	Homo sapiens	P47224	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	RASSF5	Q8WWW0	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	RASSF5	Q8WWW0	RAP2B	Homo sapiens	P61225	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24366813
Intra	RASSF5	Q8WWW0	STK3	Homo sapiens	Q13188	Anti Tag CoIP	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leukocyte Adhesion Deficiency, Type I	Leukocyte Adhesion Deficiency Leukocyte Adhesion Deficiency 1 LAD1 Lad Lymphocyte Function-Associated Antigen 1 Immunodeficiency Leukocyte Adhesion Deficiency Type I Leukocyte Adhesion Deficiency Type 1 Linear Iga Bullous Dermatosis Linear Iga Dermatosis Leukocyte-Adhesion Deficiency Syndrome Lfa1 Immunodeficiency Congenital Leukocyte Adherence Deficiency Lad-I Linear Iga Disease Leukocyte Adhesion Deficiency Syndrome Lad 1 Lfa 1 Immunodeficiency Linear Immunoglobulin A Dermatosis Leucocyte Adhesion Deficiency Type 1 Leukocyte Adhesion Molecule Deficiency Type 1
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11703	RASSF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11705	RASSF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21184	Rassf5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27700	Rassf5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RASSF5	VGNC	VGNC:100051
Rattus norvegicus	RASSF5	RGD	RGD:621694
Canis familiaris	RASSF5	VGNC	VGNC:45382
Mus musculus	RASSF5	MGD	MGI:1926375
Bos taurus	RASSF5	VGNC	VGNC:33761
Felis catus	RASSF5	VGNC	VGNC:64508
Others	RASSF5	NCBI