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RABIF - RAB interacting factor Gene

Also Known as MSS4; RASGFR3; RASGRF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5877

About RABIF

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,878,282-202,889,149 (from NCBI)

This gene has 1 transcript (splice variant) and 188 orthologues. Broad expression in testis (RPKM 8.2), brain (RPKM 4.5) and 24 other tissues.

Summary

This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011]

RABIF Products (1)

mRNA	Protein	Name
NM_002871.5	NP_002862.2	guanine nucleotide exchange factor MSS4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16541104	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	7619808	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RABIF Protein Structure

Mss4

0
100
123 a.a.

Protein Preferred Names	Protein Names
guanine nucleotide exchange factor MSS4	Ras-specific guanine-releasing factor 3

RABIF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RABIF	P47224	RAB1B	Homo sapiens	Q9H0U4	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	RAB1B	Homo sapiens	Q9H0U4	Anti Tag CoIP	33961781
Intra	RABIF	P47224	RAB1B	Homo sapiens	Q9H0U4	Validated Y2H	32296183
Intra	RABIF	P47224	RAB1B	Homo sapiens	Q9H0U4	Anti Tag CoIP	35271311
Intra	RABIF	P47224	RAB3A	Homo sapiens	P20336	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	RAB3A	Homo sapiens	P20336	Anti Tag CoIP	33961781
Intra	RABIF	P47224	RAB3A	Homo sapiens	P20336	Y2H Array	32296183
Intra	RABIF	P47224	RAB3A	Homo sapiens	P20336	Y2H Prey Pooling	25416956
Intra	RABIF	P47224	LARP1B	Homo sapiens	Q659C4-6	Validated Y2H	32296183
Intra	RABIF	P47224	LARP1B	Homo sapiens	Q659C4-6	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	LARP1B	Homo sapiens	Q659C4-6	Y2H Array	32296183
Intra	RABIF	P47224	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	RABIF	P47224	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	RABIF	P47224	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	RAB3B	Homo sapiens	P20337	Anti Tag CoIP	33961781
Intra	RABIF	P47224	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	RABIF	P47224	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	RABIF	P47224	LRMDA	Homo sapiens	A0A087WWI0	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	LRMDA	Homo sapiens	A0A087WWI0	Y2H Array	32296183
Intra	RABIF	P47224	RAB3D	Homo sapiens	O95716	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	RAB3D	Homo sapiens	O95716	Y2H Array	32296183
Intra	RABIF	P47224	RASSF5	Homo sapiens	Q8WWW0	Validated Y2H	25416956
Intra	RABIF	P47224	RAB3C	Homo sapiens	Q96E17	Validated Y2H	32296183
Intra	RABIF	P47224	RAB3C	Homo sapiens	Q96E17	Y2H Array	32296183
Intra	RABIF	P47224	RAB3C	Homo sapiens	Q96E17	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	RAB19	Homo sapiens	A4D1S5	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	RAB19	Homo sapiens	A4D1S5	Y2H Array	32296183
Intra	RABIF	P47224	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	RABIF	P47224	LMCD1	Homo sapiens	Q9NZU5	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	LMCD1	Homo sapiens	Q9NZU5	Validated Y2H	32296183
Intra	RABIF	P47224	LMCD1	Homo sapiens	Q9NZU5	Y2H Array	32296183
Intra	RABIF	P47224	EIF3F	Homo sapiens	O00303	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	EIF3F	Homo sapiens	O00303	Y2H Array	32296183
Intra	RABIF	P47224	RAB1A	Homo sapiens	P62820	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	RAB1A	Homo sapiens	P62820	Validated Y2H	32296183
Intra	RABIF	P47224	RAB1A	Homo sapiens	P62820	Anti Tag CoIP	33961781
Intra	RABIF	P47224	RAB8A	Homo sapiens	P61006	Anti Tag CoIP	33961781
Intra	RABIF	P47224	RAB8A	Homo sapiens	P61006	FRET	16541104
Intra	RABIF	P47224	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	RABIF	P47224	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	RABIF	P47224	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	RABIF	P47224	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	RABIF	P47224	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11589	RABIF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RABIF	VGNC	VGNC:107927
Rattus norvegicus	RABIF	RGD	RGD:1359331
Macaca mulatta	RABIF	VGNC	VGNC:106481
Mus musculus	RABIF	MGD	MGI:2138605
Canis familiaris	RABIF	VGNC	VGNC:45305
Bos taurus	RABIF	VGNC	VGNC:33672
Others	RABIF	NCBI