RAB3C - RAB3C, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115827

About RAB3C

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:58,582,152-58,859,394 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues and 68 paralogues. Biased expression in brain (RPKM 24.5) and adrenal (RPKM 6.1).

Summary

This gene is a member of the Ras oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

RAB3C Products (2)

mRNA Protein Name
NM_001317915.2 NP_001304844.1 ras-related protein Rab-3C isoform 2
NM_138453.4 NP_612462.1 ras-related protein Rab-3C isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
24891604 GOA
enables myosin V binding IPI
IPI: Inferred from physical interaction
24006491 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24891604 GOA
Biological Process GO Annotation Evidence References Source
involved in antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
19717423 GOA
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19717423 GOA
located in vesicle IDA
IDA: Inferred from direct assay
19717423 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB3C Protein Structure

Ras

Ras: Ras family (32 - 191)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-3C

RAB3C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB3C Q96E17 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
RAB3C Q96E17 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
RAB3C Q96E17 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
RAB3C Q96E17 VRTN Homo sapiens Q9H8Y1
Validated Y2H
32296183
Intra
RAB3C Q96E17 VRTN Homo sapiens Q9H8Y1
Y2H Array
32296183
Intra
RAB3C Q96E17 VRTN Homo sapiens Q9H8Y1
Y2H Prey Pooling
32296183
Intra
RAB3C Q96E17 ITM2B Homo sapiens Q9Y287
Y2H Array
32814053
Intra
RAB3C Q96E17 ITM2B Homo sapiens Q9Y287
Validated Y2H
32814053
Intra
RAB3C Q96E17 ITM2B Homo sapiens Q9Y287
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Warburg Micro Syndrome 1

  • Warburg Micro Syndrome

  • Micro Syndrome

  • Warbm

  • WARBM1

  • Warburg Sjo Fledelius Syndrome

  • Warburg-Sjo-Fledelius Syndrome

  • Micro Syndrome 1

  • Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Focal Epithelial Hyperplasia

  • Heck'S Disease

  • Heck Disease

  • Multifocal Epithelial Hyperplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11557 RAB3C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RAB3C VGNC VGNC:97591
Rattus norvegicus RAB3C RGD RGD:620923
Mus musculus RAB3C MGD MGI:1914545
Canis familiaris RAB3C VGNC VGNC:45284
Bos taurus RAB3C VGNC VGNC:33651
Macaca mulatta RAB3C VGNC VGNC:81541
Others RAB3C NCBI