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RAB1A - RAB1A, member RAS oncogene family Gene

Also Known as RAB1; YPT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5861

About RAB1A

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,086,854-65,130,106 (from NCBI)

This gene has 6 transcripts (splice variants), 163 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 68.0), thyroid (RPKM 58.5) and 25 other tissues.

Summary

This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

RAB1A Products (2)

mRNA	Protein	Name
NM_004161.5	NP_004152.1	ras-related protein Rab-1A isoform 1
NM_015543.2	NP_056358.1	ras-related protein Rab-1A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	17684057	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15186776	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in COPII-coated vesicle cargo loading	IMP IMP: Inferred from mutant phenotype	17684057	GOA
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	17684057	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20639577	GOA
NOT involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	17646400	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	21303926	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IGI IGI: Inferred from genetic interaction	21680502	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	17684057	GOA
NOT involved in establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	23885123	GOA
involved in growth hormone secretion	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in positive regulation of glycoprotein metabolic process	IGI IGI: Inferred from genetic interaction	21680502	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	21303926	GOA
involved in virion assembly	IGI IGI: Inferred from genetic interaction	21680502	GOA
involved in virion assembly	IMP IMP: Inferred from mutant phenotype	21680502	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17684057	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB1A Protein Structure

Ras

0
100
205 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-1A	GTP binding protein Rab1a

RAB1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB1A	P62820	RPTOR	Homo sapiens	Q8N122	Anti Bait CoIP	25446900
Intra	RAB1A	P62820	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	25446900
Intra	RAB1A	P62820	RPTOR	Homo sapiens	Q8N122	PLA	25446900
Cross	RAB1A	P62820	drrA	Legionella pneumophila	Q29ST3	Anti Tag CoIP	30323948
Intra	RAB1A	P62820	C9orf72	Homo sapiens	Q96LT7-1	Pull Down	27334615
Intra	RAB1A	P62820	C9orf72	Homo sapiens	Q96LT7-1	Anti Tag CoIP	27334615
Intra	RAB1A	P62820	C9orf72	Homo sapiens	Q96LT7-2	Anti Tag CoIP	27334615
Intra	RAB1A	P62820	C9orf72	Homo sapiens	Q96LT7-2	Pull Down	27334615
Intra	RAB1A	P62820	MTOR	Homo sapiens	P42345	Anti Bait CoIP	25446900
Intra	RAB1A	P62820	MTOR	Homo sapiens	P42345	Anti Tag CoIP	25446900
Intra	RAB1A	P62820	MTOR	Homo sapiens	P42345	PLA	25446900
Intra	RAB1A	P62820	OCRL	Homo sapiens	Q01968	Pull Down	16902405
Intra	RAB1A	P62820	RABIF	Homo sapiens	P47224	Anti Tag CoIP	33961781
Intra	RAB1A	P62820	RABIF	Homo sapiens	P47224	Y2H Array	32296183
Cross	RAB1A	P62820	drrA	Legionella pneumophila subsp. pneumophila	Q5ZSQ3	Comig Non-Denat Gel	19942850
Cross	RAB1A	P62820	drrA	Legionella pneumophila subsp. pneumophila	Q5ZSQ3	X-Ray Diffraction	19942850
Cross	RAB1A	P62820	drrA	Legionella pneumophila subsp. pneumophila	Q5ZSQ3	ITC	19942850
Intra	RAB1A	P62820	GDI1	Homo sapiens	P31150	Anti Tag CoIP	35271311
Intra	RAB1A	P62820	GDI1	Homo sapiens	P31150	Pull Down	19942850
Intra	RAB1A	P62820	GDI1	Homo sapiens	P31150	Anti Tag CoIP	33961781
Intra	RAB1A	P62820	GDI1	Homo sapiens	P31150	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87057	Rab1A Antibody (YA6750)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Choroideremia	CHM Tcd Progressive Tapetochoroidal Dystrophy Choroidal Sclerosis Tapetochoroidal Dystrophy, Progressive Progressive Choroidal Atrophy Tapetochoroidal Dystrophy
Spinocerebellar Ataxia, Autosomal Recessive 6	SCAR6 Norwegian Infantile Onset Ataxia Autosomal Recessive Spinocerebellar Ataxia 6 Autosomal Recessive Spinocerebellar Ataxia Type 6 Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia Cerebellar Ataxia, Infantile Nonprogressive, Autosomal Recessive Spinocerebellar Ataxia Autosomal Recessive 6 Cerebellar Ataxia Infantile Nonprogressive Autosomal Recessive
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Esophageal Neuroendocrine Tumor	Esophageal Neuroendocrine Tumour Neuroendocrine Tumor Of Esophagus Neuroendocrine Tumour Of Oesophagus
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Rectum Adenocarcinoma	Rectal Adenocarcinoma Adenocarcinoma Of Rectum
Rectal Benign Neoplasm	Neoplasm Of Rectum Rectal Tumor Rectum Neoplasm Neoplasm Of The Rectum Rectal Neoplasms Primary Rectal Cancer Rectal Ampulla Cancer Cancer Of The Rectum Carcinoma Of Rectum Primary Malignant Neoplasm Of Rectum Rectal Cancer Rectal Carcinoma
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16997	Itacitinib	Inhibitor	99.97%	Yes
HY-110174	NAB2	Degrader	99.69%	Unkown
HY-16997A	Itacitinib adipate	Inhibitor	99.18%	Yes
HY-156242	BQZ-485	Inducer	/	Unkown
HY-RS11528	RAB1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22758	Rab1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAB1A	VGNC	VGNC:106204
Bos taurus	RAB1A	VGNC	VGNC:33626
Felis catus	RAB1A	VGNC	VGNC:81164
Mus musculus	RAB1A	MGD	MGI:97842
Canis familiaris	RAB1A	VGNC	VGNC:45259
Rattus norvegicus	RAB1A	RGD	RGD:619736
Others	RAB1A	NCBI