1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Itacitinib (Synonyms: INCB039110)

Cat. No.: HY-16997 Purity: 99.87%
Handling Instructions

Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.

For research use only. We do not sell to patients.

Itacitinib Chemical Structure

Itacitinib Chemical Structure

CAS No. : 1334298-90-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 170 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
1 mg USD 90 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg USD 1950 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of Itacitinib:

View All JAK Isoform Specific Products:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.

IC50 & Target[1]

JAK1

 

In Vitro

Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (54.20 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8067 mL 9.0333 mL 18.0665 mL
5 mM 0.3613 mL 1.8067 mL 3.6133 mL
10 mM 0.1807 mL 0.9033 mL 1.8067 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

553.51

Formula

C₂₆H₂₃F₄N₉O

CAS No.

1334298-90-6

SMILES

N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.87%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Itacitinib
Cat. No.:
HY-16997
Quantity:

Itacitinib

Cat. No.: HY-16997