1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Itacitinib (Synonyms: INCB039110; INCB-039110; INCB 039110)

Cat. No.: HY-16997 Purity: 99.87%
Data Sheet SDS Handling Instructions

Itacitinib (INCB039110) is an oral selective JAK1 inhibitor.

For research use only. We do not sell to patients.
Itacitinib Chemical Structure

Itacitinib Chemical Structure

CAS No. : 1334298-90-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $426 In-stock
1 mg $150 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Itacitinib (INCB039110) is an oral selective JAK1 inhibitor. Target: JAK1 in vitro: Itacitinib is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1. Itacitinib potently inhibits OCT2-mediated uptake of creatinine as well as MATE1-/MATE2-K-mediated efflux of creatinine. Itacitinib causes a dose-dependent decrease in transcellular transport of creatinine with weaker net inhibition compared with the effects on individual transporters.

References
M.Wt

553.51

Formula

C₂₆H₂₃F₄N₉O

CAS No.

1334298-90-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.87%

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Itacitinib
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