LZTS1 - leucine zipper tumor suppressor 1 Gene

Also Known as F37; FEZ1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11178

About LZTS1

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:20,246,165-20,303,963 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 4.1), brain (RPKM 3.1) and 19 other tissues.

Summary

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the CDK1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of Cancer. [provided by RefSeq, Nov 2009]

LZTS1 Products (2)

mRNA Protein Name
NM_001362884.2 NP_001349813.1 leucine zipper putative tumor suppressor 1
NM_021020.5 NP_066300.1 leucine zipper putative tumor suppressor 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17349584 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LZTS1 Protein Structure

Fez1

Fez1: Fez1 (380 - 566)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 596 a.a.
Protein Preferred Names Protein Names

leucine zipper putative tumor suppressor 1

  • F37/Esophageal cancer-related gene-coding leucine-zipper motif

LZTS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LZTS1 Q9Y250 CEP83 Homo sapiens Q9Y592-2
Validated Y2H
32296183
Intra
LZTS1 Q9Y250 LSM2 Homo sapiens Q9Y333
Validated Y2H
32296183
Intra
LZTS1 Q9Y250 CDC25C Homo sapiens P30307
Anti Bait CoIP
17349584
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Ehlers-Danlos Syndrome

  • Eds

  • Cutis Hyperelastica

  • Elastic Skin

  • Ehlers-Danlos Syndromes

  • Ed Syndrome

  • Ehlers Danlos Syndrome

  • Ehlers Danlos Disease

  • Eds - [Ehlers-Danlos Syndrome]
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Hypermobility Syndrome

  • Benign Joint Hypermobility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07934 LZTS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22620 Lzts1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29135 Lzts1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LZTS1 RGD RGD:708565
Bos taurus LZTS1 VGNC VGNC:31121
Mus musculus LZTS1 MGD MGI:2684762
Macaca mulatta LZTS1 VGNC VGNC:74283
Canis familiaris LZTS1 VGNC VGNC:42905
Felis catus LZTS1 VGNC VGNC:63352
Others LZTS1 NCBI