CDC25C - cell division cycle 25C Gene

Also Known as CDC25; PPP1R60

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 995

About CDC25C

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,285,265-138,338,355 (from NCBI)

This gene has 9 transcripts (splice variants), 122 orthologues and 2 paralogues. Biased expression in testis (RPKM 7.7), bone marrow (RPKM 1.3) and 8 other tissues.

Summary

This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into Mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]

CDC25C Products (8)

mRNA	Protein	Name
NM_001287582.2	NP_001274511.1	M-phase inducer phosphatase 3 isoform a
NM_001287583.2	NP_001274512.1	M-phase inducer phosphatase 3 isoform c
NM_001318098.2	NP_001305027.1	M-phase inducer phosphatase 3 isoform e
NM_001364026.1	NP_001350955.1	M-phase inducer phosphatase 3 isoform f
NM_001364027.1	NP_001350956.1	M-phase inducer phosphatase 3 isoform g
NM_001364028.1	NP_001350957.1	M-phase inducer phosphatase 3 isoform h
NM_001790.5	NP_001781.2	M-phase inducer phosphatase 3 isoform a
NM_022809.4	NP_073720.1	M-phase inducer phosphatase 3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	10037602	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9543386	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	9543386	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G2/M transition of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	2195549	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	14968113	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC25C Protein Structure

M-inducer_phosp

Rhodanese

0
100
200
300
400
473 a.a.

Protein Preferred Names	Protein Names
M-phase inducer phosphatase 3	CDC25 homolog C

CDC25C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC25C	P30307	LZTS1	Homo sapiens	Q9Y250	Anti Tag CoIP	17349584
Intra	CDC25C	P30307	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	27880917
Intra	CDC25C	P30307	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	CDC25C	P30307	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CDC25C	P30307	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	27880917
Intra	CDC25C	P30307	YWHAB	Homo sapiens	P31946	Pull Down	28330616
Intra	CDC25C	P30307	YWHAB	Homo sapiens	P31946	Anti Bait CoIP	19470455
Intra	CDC25C	P30307	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	27880917
Intra	CDC25C	P30307	CDK1	Homo sapiens	P06493	Anti Tag CoIP	17349584
Intra	CDC25C	P30307	CDK1	Homo sapiens	P06493	Anti Tag CoIP	27880917
Intra	CDC25C	P30307	PLK1	Homo sapiens	P53350	Pull Down	12595692
Intra	CDC25C	P30307	CHEK1	Homo sapiens	O14757	Protein Kinase Assay	16330544
Intra	CDC25C	P30307	CHEK1	Homo sapiens	O14757	Protein Kinase Assay	11836499

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC25C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82879	Cdc25C Antibody (YA2624)	WB, IHC-P, ICC/IF, IP, FC	Human
HY-P84245	Cdc25C Antibody (YA3942)	WB, IHC-P, ELISA	Human
HY-P84245A	Cdc25C Antibody (YA3942)(PBS only)	WB, IHC-P, ELISA	Human
HY-P85096	Cdc25C Antibody (YA4788)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P86209	Cdc25C Antibody (YA5901)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108543	NSC 95397		99.0%	Unkown
HY-100034	NSC 663284	Inhibitor	99.29%	Unkown
HY-N5112A	β,β-Dimethylacrylalkannin		99.36%	Unkown
HY-107407	SB-218078		98.30%	Unkown
HY-112356	Scytonemin	Inhibitor	98.12%	Unkown
HY-132578	M5N36	Inhibitor	98.00%	Unkown
HY-112776A	BN82002 hydrochloride	Inhibitor	99.36%	Unkown
HY-121065	BN-82685	Inhibitor	99.05%	Unkown
HY-128769	M2N12	Inhibitor	98.19%	Unkown
HY-N3000	6-Methoxydihydrosanguinarine		99.88%	Unkown
HY-P2948	Protein serine/threonine kinase		/	Unkown
HY-112776	BN82002	Inhibitor	/	Unkown
HY-118529	JUN-1111	Inhibitor	98.57%	Unkown
HY-N3968	Goniothalamin		98.0%	Unkown
HY-172807	p38α-IN-9	Inhibitor	/	Unkown
HY-181011	PROTAC Cdc25 degrader-1		/	Unkown
HY-182382	Anticancer agent 311		/	Unkown
HY-185446	KZ-02	Inhibitor	/	Unkown
HY-28086	CDC25-IN-2	Inhibitor	/	Unkown
HY-N3000A	6-Methoxydihydrosanguinarine hydrochloride		/	Unkown
HY-P10574	Phosphorylated CHKtide		/	Unkown
HY-RS02293	CDC25C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18853	Cdc25c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25345	Cdc25c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W276819	PLK1-IN-9	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC25C	VGNC	VGNC:60651
Rattus norvegicus	CDC25C	RGD	RGD:1311875
Mus musculus	CDC25C	MGD	MGI:88350
Macaca mulatta	CDC25C	VGNC	VGNC:70796
Canis familiaris	CDC25C	VGNC	VGNC:38991
Bos taurus	CDC25C	VGNC	VGNC:27064
Others	CDC25C	NCBI