2. PROTAC Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. PROTACs Phosphatase Apoptosis Reactive Oxygen Species (ROS)
  4. PROTAC Cdc25 degrader-1

PROTAC Cdc25 degrader-1 (Compound D3) is an efficient Cdc25 PROTAC degrader. Its DC50 values for Cdc25A, Cdc25B, and Cdc25C are 0.97, 2.02, and 4.67 μM respectively. PROTAC Cdc25 degrader-1 induces cell cycle arrest and apoptosis in cancer cells and inhibits cell migration ability. PROTAC Cdc25 degrader-1 significantly increases the ROS level. PROTAC Cdc25 degrader-1 can be used for the study of colorectal adenocarcinoma.
(Pink: Phosphatase Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).

For research use only. We do not sell to patients.

PROTAC Cdc25 degrader-1

PROTAC Cdc25 degrader-1 Chemical Structure

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PROTAC Cdc25 degrader-1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC Cdc25 degrader-1 (Compound D3) is an efficient Cdc25 PROTAC degrader. Its DC50 values for Cdc25A, Cdc25B, and Cdc25C are 0.97, 2.02, and 4.67 μM respectively. PROTAC Cdc25 degrader-1 induces cell cycle arrest and apoptosis in cancer cells and inhibits cell migration ability. PROTAC Cdc25 degrader-1 significantly increases the ROS level. PROTAC Cdc25 degrader-1 can be used for the study of colorectal adenocarcinoma[1]. (Pink: Phosphatase Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).

IC50 & Target[1]

VHL

 

Molecular Weight

735.29

Formula

C37H43ClN6O6S
SMILES

O[C@@H]1C[C@H](N(C1)C([C@H](C(C)(C)C)NC(CCCCNC(C2=O)=C(C(C3=C2C=CC=N3)=O)Cl)=O)=O)C(N[C@H](C4=CC=C(C=C4)C5=C(N=CS5)C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC Cdc25 degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC Cdc25 degrader-1PROTACsPhosphataseApoptosisReactive Oxygen Species (ROS)Cdc25 phosphataseprotein degradationantitumor activitycell cycle arrestapoptosisHCT-15 xenograft modelpharmacokineticsInhibitorinhibitorinhibit

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