1. Cell Cycle/DNA Damage
  2. CDK
  3. M2N12

M2N12 

Cat. No.: HY-128769
Handling Instructions

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09  μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity.

For research use only. We do not sell to patients.

M2N12 Chemical Structure

M2N12 Chemical Structure

CAS No. : 2376577-06-7

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Description

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09  μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity[1].

In Vitro

M2N12 (0-20 μM; 72 hours) has cytotoxic activity against five tumor cell lines and a normal cell line including A-549, MDA-MB-231, KB, KB-VIN, MCF-7 and HBE (IC50=3.92 μM, 4.63 μM, 5.05 μM, 6.81 μM, 4.71 μM and 6.00 μM, respectively)[1].

Molecular Weight

393.83

Formula

C₂₀H₁₆ClN₅O₂

CAS No.

2376577-06-7

SMILES

O=C(C(Cl)=C1NCC2=CN(CC3=CC=C(C)C=C3)N=N2)C4=C(N=CC=C4)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

M2N12CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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