1. Cell Cycle/DNA Damage
  2. CDK
  3. M2N12

M2N12 

Cat. No.: HY-128769 Purity: 98.27%
Handling Instructions

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09  μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research.

For research use only. We do not sell to patients.

M2N12 Chemical Structure

M2N12 Chemical Structure

CAS No. : 2376577-06-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 418 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 418 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09  μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research[1].

In Vitro

M2N12 (0-20 μM; 72 hours) has cytotoxic activity against five tumor cell lines and a normal cell line including A-549, MDA-MB-231, KB, KB-VIN, MCF-7 and HBE (IC50=3.92 μM, 4.63 μM, 5.05 μM, 6.81 μM, 4.71 μM and 6.00 μM, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

393.83

Formula

C20H16ClN5O2

CAS No.
SMILES

O=C(C(Cl)=C1NCC2=CN(CC3=CC=C(C)C=C3)N=N2)C4=C(N=CC=C4)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 11.11 mg/mL (28.21 mM; ultrasonic and warming and heat to 67°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5392 mL 12.6958 mL 25.3917 mL
5 mM 0.5078 mL 2.5392 mL 5.0783 mL
10 mM 0.2539 mL 1.2696 mL 2.5392 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1.11 mg/mL (2.82 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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M2N12
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