LSM2 - LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Also Known as G7B; snRNP; C6orf28; YBL026W

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57819

About LSM2

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,797,396-31,806,966 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in lymph node (RPKM 15.9), appendix (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

LSM2 Products (1)

mRNA	Protein	Name
NM_021177.5	NP_067000.1	U6 snRNA-associated Sm-like protein LSm2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within mRNA catabolic process	IDA IDA: Inferred from direct assay	12515382	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
acts upstream of or within spliceosomal tri-snRNP complex assembly	IDA IDA: Inferred from direct assay	10523320	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12515382	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10523320	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM2 Protein Structure

LSM

0
95 a.a.

Protein Preferred Names	Protein Names
U6 snRNA-associated Sm-like protein LSm2	LSM2 U6 small nuclear RNA and mRNA degradation associated

LSM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LSM2	Q9Y333	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	LSM2	Q9Y333	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	15231747
Intra	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	22365833
Intra	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	14667819
Intra	LSM2	Q9Y333	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H	15231747
Intra	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H Array	32296183
Intra	LSM2	Q9Y333	ZNF408	Homo sapiens	Q9H9D4	Y2H	14667819
Intra	LSM2	Q9Y333	ZNF408	Homo sapiens	Q9H9D4	Y2H	15231747
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	GMS	19628699
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	22365833
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	14667819
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	15231747
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Ion Exchange Chrom	19628699
Intra	LSM2	Q9Y333	SNRPE	Homo sapiens	P62304	Y2H	14667819
Intra	LSM2	Q9Y333	SNRPE	Homo sapiens	P62304	Y2H	15231747
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Pooling	16169070
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	GMS	19628699
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	21516116
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Lumier	37398436
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	31467278
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Ion Exchange Chrom	19628699
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	25416956
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	SLC	31467278
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	SLC	27107012
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	14667819
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	15231747
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	BRET	37398436
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	BFG-2H	27107012
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	32296183
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	22365833
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	14667819
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Ion Exchange Chrom	19628699
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	GMS	19628699
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H Array	32296183
Intra	LSM2	Q9Y333	SNRPB	Homo sapiens	P14678-2	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	SNRPB	Homo sapiens	P14678-2	Y2H Array	32296183
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Ion Exchange Chrom	19628699
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	GMS	19628699
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H Array	32296183
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H	22365833
Intra	LSM2	Q9Y333	MAGEA3	Homo sapiens	P43357	Y2H Array	32296183
Intra	LSM2	Q9Y333	MAGEA3	Homo sapiens	P43357	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	LSM2	Q9Y333	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H	22365833
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Array	25416956
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Array	32296183
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Validated Y2H	25416956
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM12	Homo sapiens	Q3MHD2	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM12	Homo sapiens	Q3MHD2	Y2H Array	32296183
Intra	LSM2	Q9Y333	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	LSM2	Q9Y333	DNAAF11	Homo sapiens	Q86X45	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	DNAAF11	Homo sapiens	Q86X45	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mixed Connective Tissue Disease	Sharp Syndrome Mctd Connective Tissue Disease Overlap Syndrome Mixed Collagen Vascular Disease Mctd - [Mixed Connective Tissue Disease]
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Cystic Echinococcosis	Echinococcus Granulosus Infection Echinococcus Granulosus Infection Of Lung Echinococcus Granulosus Echinococcus Granulosus Infection Of Thyroid Echinococcus Granulosus Infectious Disease Echinococcus Granulosus Infectious Disease Of Liver Echinococcus Granulosus Infectious Disease Of Thyroid Liver Echinococcus Granulosus Lung Echinococcus Granulosus Thyroid Echinococcus Granulosus Unilocular Echinococcosis Unilocular Hydatid Disease Hydatid Disease Hydatidosis Echinococcosis
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07857	LSM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LSM2	VGNC	VGNC:81088
Bos taurus	LSM2	VGNC	VGNC:31054
Felis catus	LSM2	VGNC	VGNC:102452
Rattus norvegicus	LSM2	RGD	RGD:1598536
Mus musculus	LSM2	MGD	MGI:90676
Others	LSM2	NCBI