DNAAF11 - dynein axonemal assembly factor 11 Gene

Also Known as LRTP; tilB; LRRC6; TSLRP; CILD19

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 23639

Summary

The protein encoded by this gene contains several leucine-rich repeat domains and appears to be involved in the motility of cilia. Defects in this gene are a cause of primary ciliary dyskinesia-19 (CILD19). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 11 and 22. [provided by RefSeq, Apr 2016]

DNAAF11 Products (1)

mRNA Protein Name
XM_054360229.1 XP_054216204.1 dynein axonemal assembly factor 11 isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23891469 GOA
Biological Process GO Annotation Evidence References Source
involved in axonemal dynein complex assembly IMP
IMP: Inferred from mutant phenotype
23527195 GOA
involved in cilium movement IMP
IMP: Inferred from mutant phenotype
23122589 GOA
involved in epithelial cilium movement involved in determination of left/right asymmetry IMP
IMP: Inferred from mutant phenotype
23122589 GOA
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
23122589 GOA
involved in inner dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23122589 GOA
involved in motile cilium assembly IMP
IMP: Inferred from mutant phenotype
23122589 GOA
involved in outer dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23122589 GOA
involved in protein localization to motile cilium IMP
IMP: Inferred from mutant phenotype
23527195 GOA
involved in reproductive system development IMP
IMP: Inferred from mutant phenotype
23122589 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
23122589 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
23122589 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein axonemal assembly factor 11

  • leucine rich repeat containing 6

  • protein TILB homolog

  • seahorse

  • testis-specific leucine-rich repeat protein

DNAAF11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNAAF11 Q86X45 SSX7 Homo sapiens Q7RTT5
Y2H Prey Pooling
32296183
Intra
DNAAF11 Q86X45 SSX7 Homo sapiens Q7RTT5
Y2H Array
32296183
Intra
DNAAF11 Q86X45 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
DNAAF11 Q86X45 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
DNAAF11 Q86X45 LRCH3 Homo sapiens Q96II8-3
Validated Y2H
32296183
Intra
DNAAF11 Q86X45 PODN Homo sapiens Q7Z5L7-3
Y2H Prey Pooling
32296183
Intra
DNAAF11 Q86X45 PODN Homo sapiens Q7Z5L7-3
Y2H Array
32296183
Intra
DNAAF11 Q86X45 LSM2 Homo sapiens Q9Y333
Validated Y2H
32296183
Intra
DNAAF11 Q86X45 SCRIB Homo sapiens Q14160
Anti Tag CoIP
33961781
Intra
DNAAF11 Q86X45 TERF1 Homo sapiens P54274-2
Y2H Prey Pooling
32296183
Intra
DNAAF11 Q86X45 TERF1 Homo sapiens P54274-2
Y2H Array
32296183
Intra
DNAAF11 Q86X45 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
DNAAF11 Q86X45 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
DNAAF11 Q86X45 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
DNAAF11 Q86X45 TTC23L Homo sapiens Q6PF05
Y2H Prey Pooling
32296183
Intra
DNAAF11 Q86X45 TTC23L Homo sapiens Q6PF05
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03839 DNAAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown