SCRIB - scribble planar cell polarity protein Gene

Also Known as CRIB1; SCRB1; SCRIB1; Vartul; oSCRIB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23513

About SCRIB

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,790,925-143,815,773 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 187 orthologues, 31 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 9.3), skin (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many Other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SCRIB Products (2)

mRNA	Protein	Name
NM_015356.5	NP_056171.3	protein scribble homolog isoform b
NM_182706.5	NP_874365.3	protein scribble homolog isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15182672	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	27380321	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	19041750	GOA
involved in apoptotic process involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	19041750	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18716323	GOA
involved in cell population proliferation	IDA IDA: Inferred from direct assay	16965391	GOA
involved in cell-cell adhesion	IGI IGI: Inferred from genetic interaction	16344308	GOA
involved in establishment of apical/basal cell polarity	IMP IMP: Inferred from mutant phenotype	19041750	GOA
involved in negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	16965391	GOA
involved in negative regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	34535749	GOA
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	22095531	GOA
involved in polarized epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	27380321	GOA
involved in positive chemotaxis	IMP IMP: Inferred from mutant phenotype	18716323	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19041750	GOA
involved in positive regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	15775968	GOA
involved in protein localization to adherens junction	IMP IMP: Inferred from mutant phenotype	16611247	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Scrib-APC-beta-catenin complex	IDA IDA: Inferred from direct assay	16611247	GOA
located in adherens junction	IDA IDA: Inferred from direct assay	16965391	GOA
colocalizes with cell leading edge	IDA IDA: Inferred from direct assay	18716323	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	15649318	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19386766	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	16611247	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15182672	GOA
colocalizes with postsynaptic membrane	IDA IDA: Inferred from direct assay	15182672	GOA
colocalizes with presynaptic membrane	IDA IDA: Inferred from direct assay	15182672	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCRIB Protein Structure

LRR_8

LRR_4

PDZ

0
300
600
900
1200
1500
1630 a.a.

Protein Preferred Names	Protein Names
protein scribble homolog	scribbled homolog

SCRIB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCRIB	Q14160	VEPH1	Homo sapiens	Q14D04	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	YAP1	Homo sapiens	P46937	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	ARHGEF16	Homo sapiens	Q5VV41	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	TANC1	Homo sapiens	Q9C0D5	MST	30126976
Intra	SCRIB	Q14160	TANC1	Homo sapiens	Q9C0D5	P8 Filamentous Phage	30126976
Cross	SCRIB	Q14160	E6	Human papillomavirus	P06427	SLC	22898364
Cross	SCRIB	Q14160	E6	Human papillomavirus	P06427	Phage Display	24550280
Intra	SCRIB	Q14160	ATP2B2	Homo sapiens	Q01814	P8 Filamentous Phage	30126976
Cross	SCRIB	Q14160	E6	Human papillomavirus	P03126	Pull Down	16103886
Cross	SCRIB	Q14160	E6	Human papillomavirus	P03126	Phage Display	24550280
Cross	SCRIB	Q14160	E6	Human papillomavirus	P03126	SLC	22898364
Intra	SCRIB	Q14160	b7z2y1_human	Homo sapiens	B7Z2Y1	Phage Display	24550280
Intra	SCRIB	Q14160	NXPE2	Homo sapiens	Q96DL1	Phage Display	24550280
Intra	SCRIB	Q14160	SLC15A5	Homo sapiens	A6NIM6	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	FAM163B	Homo sapiens	P0C2L3	P8 Filamentous Phage	30126976
Cross	SCRIB	Q14160	E6	Human papillomavirus	P24835	Phage Display	24550280
Cross	SCRIB	Q14160	E6	Human papillomavirus	P24835	SLC	22898364
Cross	SCRIB	Q14160	tax	Human T-cell leukemia virus	P0C213	Phage Display	24550280
Cross	SCRIB	Q14160	tax	Human T-cell leukemia virus	P0C222	Phage Display	24550280
Intra	SCRIB	Q14160	KCNJ12	Homo sapiens	Q14500	Phage Display	24550280
Intra	SCRIB	Q14160	KCNJ12	Homo sapiens	Q14500	P8 Filamentous Phage	30126976
Cross	SCRIB	Q14160	E6	Human papillomavirus	P06463	Pull Down	16103886
Cross	SCRIB	Q14160	E6	Human papillomavirus	P06463	SLC	22898364
Intra	SCRIB	Q14160	RPS6KA2	Homo sapiens	Q15349	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	RPS6KA2	Homo sapiens	Q15349	ITC	30126976
Intra	SCRIB	Q14160	RPS6KA2	Homo sapiens	Q15349	NMR	29144123
Intra	SCRIB	Q14160	RPS6KA2	Homo sapiens	Q15349	MST	30126976
Intra	SCRIB	Q14160	RPS6KA2	Homo sapiens	Q15349	NMR	30126976
Intra	SCRIB	Q14160	TSHR	Homo sapiens	P16473	Pull Down	15775968
Intra	SCRIB	Q14160	TSHR	Homo sapiens	P16473	Anti Bait CoIP	15775968
Intra	SCRIB	Q14160	ADAM22	Homo sapiens	Q9P0K1	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	ADAM22	Homo sapiens	Q9P0K1	Phage Display	24550280
Intra	SCRIB	Q14160	WTIP	Homo sapiens	A6NIX2	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	NET1	Homo sapiens	Q7Z628	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	PHLPP1	Homo sapiens	O60346	Anti Tag CoIP	33961781
Intra	SCRIB	Q14160	MCC	Homo sapiens	P23508	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	MCC	Homo sapiens	P23508	NMR	29144123
Intra	SCRIB	Q14160	MCC	Homo sapiens	P23508	Anti Tag CoIP	33961781
Intra	SCRIB	Q14160	MCC	Homo sapiens	P23508	ITC	30126976
Intra	SCRIB	Q14160	MCC	Homo sapiens	P23508	Anti Bait CoIP	19555689
Intra	SCRIB	Q14160	MCC	Homo sapiens	P23508	IF	19555689
Intra	SCRIB	Q14160	MCC	Homo sapiens	P23508	MST	30126976
Intra	SCRIB	Q14160	FRMPD4	Homo sapiens	Q14CM0	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	CYSLTR2	Homo sapiens	Q9NS75	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	SLC6A12	Homo sapiens	P48065	Phage Display	24550280
Intra	SCRIB	Q14160	CRHR1	Homo sapiens	P34998	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	ADRA1D	Homo sapiens	P25100	Phage Display	24550280
Intra	SCRIB	Q14160	ADRA1D	Homo sapiens	P25100	TAP	26617989
Intra	SCRIB	Q14160	ATP2B1	Homo sapiens	P20020	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	MAPK12	Homo sapiens	P53778	IF	24550280
Intra	SCRIB	Q14160	MAPK12	Homo sapiens	P53778	ITC	30126976
Intra	SCRIB	Q14160	MAPK12	Homo sapiens	P53778	Anti Tag CoIP	24550280
Intra	SCRIB	Q14160	MAPK12	Homo sapiens	P53778	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	MAPK12	Homo sapiens	P53778	Phage Display	24550280
Intra	SCRIB	Q14160	GUCY1A2	Homo sapiens	P33402	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	GUCY1A2	Homo sapiens	P33402	IF	24550280
Intra	SCRIB	Q14160	GUCY1A2	Homo sapiens	P33402	Anti Tag CoIP	24550280
Intra	SCRIB	Q14160	GUCY1A2	Homo sapiens	P33402	Phage Display	24550280
Cross	SCRIB	Q14160	Fat1	Mus musculus	Q9QXA3	Pull Down	19439659
Cross	SCRIB	Q14160	Fat1	Mus musculus	Q9QXA3	Anti Tag CoIP	19439659
Intra	SCRIB	Q14160	KCNJ2	Homo sapiens	P63252	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	KCNJ4	Homo sapiens	P48050	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	KCNJ4	Homo sapiens	P48050	Phage Display	24550280
Intra	SCRIB	Q14160	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	24550280
Intra	SCRIB	Q14160	ARHGEF7	Homo sapiens	Q14155	Anti Bait CoIP	19041750
Intra	SCRIB	Q14160	ARHGEF7	Homo sapiens	Q14155	Phage Display	24550280
Intra	SCRIB	Q14160	ARHGEF7	Homo sapiens	Q14155	TAP	26617989
Intra	SCRIB	Q14160	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	33961781
Intra	SCRIB	Q14160	ARHGEF7	Homo sapiens	Q14155	IF	24550280
Intra	SCRIB	Q14160	DNM1L	Homo sapiens	O00429	Phage Display	24550280
Intra	SCRIB	Q14160	PKP4	Homo sapiens	Q99569	IF	24550280
Intra	SCRIB	Q14160	PKP4	Homo sapiens	Q99569	Anti Tag CoIP	24550280
Intra	SCRIB	Q14160	PKP4	Homo sapiens	Q99569	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	PKP4	Homo sapiens	Q99569	Phage Display	24550280
Intra	SCRIB	Q14160	CTNND2	Homo sapiens	Q9UQB3	Phage Display	24550280
Intra	SCRIB	Q14160	CTNND2	Homo sapiens	Q9UQB3	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	APC	Homo sapiens	P25054	CoIP	16611247
Intra	SCRIB	Q14160	APC	Homo sapiens	P25054	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	APC	Homo sapiens	P25054	Fluorescence	16611247
Intra	SCRIB	Q14160	MAPK3	Homo sapiens	P27361	Pull Down	20622900
Intra	SCRIB	Q14160	FASTKD5	Homo sapiens	Q7L8L6	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	WWTR1	Homo sapiens	Q9GZV5	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	RALBP1	Homo sapiens	Q15311	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	RALBP1	Homo sapiens	Q15311	Phage Display	24550280
Intra	SCRIB	Q14160	DNAAF11	Homo sapiens	Q86X45	Anti Tag CoIP	25036637
Intra	SCRIB	Q14160	RPS6KA1	Homo sapiens	Q15418	P8 Filamentous Phage	30126976
Intra	SCRIB	Q14160	RPS6KA1	Homo sapiens	Q15418	MST	30126976

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Tick-Borne Encephalitis	Siberian Tick-Borne Encephalitis Encephalitis, Tick-Borne Central European Encephalitis Far Eastern Tbe Russian Spring-Summer Encephalitis Taiga Encephalitis West-Siberian Encephalitis Western European Tick-Borne Encephalitis Tbe Encephalitis Tick-Borne Encephalitis, Central European Encephalitis, Far Eastern Russian
Myelomeningocele	Meningomyelocele
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Spinal Cord Lipoma	Lipoma Of Spinal Cord
Tethered Spinal Cord Syndrome	Spinal Dysraphism Tethered Cord Syndrome Occult Spinal Dysraphism Occult Spinal Dysraphism Sequence Segmental Vertebral Anomalies Tethered Spinal Cord Disease Tethered Cord Spina Bifida Occulta Cryptomerorachischisis Spina Bifida Occulta With Tethered Spinal Cord Sbo - [Spina Bifida Occulta]
Atrial Septal Defect 2	ASD2 Atrial Heart Septal Defect 2 Atrial Septal Defect-2 Asd Ii Septal Defect, Atrial, Type 2
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175276	JNK-IN-24	Inhibitor	/	Unkown
HY-RS12562	SCRIB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCRIB	RGD	RGD:1565055
Canis familiaris	SCRIB	VGNC	VGNC:45931
Bos taurus	SCRIB	VGNC	VGNC:34365
Mus musculus	SCRIB	MGD	MGI:2145950
Felis catus	SCRIB	VGNC	VGNC:81694
Others	SCRIB	NCBI