NET1 - neuroepithelial cell transforming 1 Gene

Also Known as NET1A; ARHGEF8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10276

About NET1

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,412,557-5,459,056 (from NCBI)

This gene has 6 transcripts (splice variants), 267 orthologues and 8 paralogues. Ubiquitous expression in colon (RPKM 43.6), small intestine (RPKM 31.5) and 25 other tissues.

Summary

This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

NET1 Products (2)

mRNA Protein Name
NM_001047160.3 NP_001040625.1 neuroepithelial cell-transforming gene 1 protein isoform 1
NM_005863.5 NP_005854.2 neuroepithelial cell-transforming gene 1 protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24550280 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
21373644 GOA
involved in cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
21373644 GOA
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
21373644 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21373644 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NET1 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (179 - 354)

PH

PH: PH domain (394 - 500)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 596 a.a.
Protein Preferred Names Protein Names

neuroepithelial cell-transforming gene 1 protein

  • Rho guanine nucleotide exchange factor (GEF) 8

NET1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NET1 Q7Z628 SCRIB Homo sapiens Q14160
Phage Display
24550280
Cross: Cross-species interaction Intra: Intraspecies interaction

NET1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811261 NET1 Antibody WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Ewing Sarcoma

  • Neuroepithelioma

  • Ewing'S Tumor

  • Primitive Neuroectodermal Tumor

  • Ewings Sarcoma

  • Ewing'S Sarcoma

  • Peripheral Neuroepithelioma

  • ES

  • Ewings Sarcoma-Primitive Neuroectodermal Tumor

  • Localized Peripheral Primitive Neuroectodermal Tumor

  • Peripheral Primitive Neuroectodermal Tumor

  • Ewing Tumor

  • Sarcoma, Ewing'S

  • Ewing Family Of Tumors

  • Extraosseous Ewing Tumor

  • Askin Tumor

  • Ewing'S Family Localized Tumor

  • Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing Sarcoma

  • Localized Ewing'S Sarcoma

  • Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing'S Tumor

  • Pnet Of Thoracopulmonary Region

  • Tumor Of The Ewing Family

  • Skeletal Ewing Sarcoma

  • Osseous Ewing Sarcoma

  • Ppnet

  • Peripheral Pnet

  • Extraskeletal Ewing Sarcoma

  • Eoe

  • Extraosseous Ewing Sarcoma

  • Extraskeletal Ewing Tumor

  • Esft

  • Ewing Sarcoma Family Of Tumors

  • Pne

  • Pnet

  • Pnet Of The Chest Wall

  • Sarcoma, Ewing

  • Neuroectodermal Tumors, Primitive, Peripheral

  • Neuroectodermal Tumor, Primitive

  • Disorder Of Eye

  • Askin'S Tumor

  • Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

  • Neuroepithelioma, Peripheral
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-15472 PRX-08066 97.46% Phase 2
HY-15472A PRX-08066 maleate / Phase 2
HY-19471 (rac)-ZK-304709 / Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09621 NTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131171 3β,5α-Tetrahydronorethisterone / Unkown
HY-RS09212 NET1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11209 PRPF38B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13306 SLC6A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13314 SLC6A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15157 TSPAN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-172029 3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride / Unkown
HY-RS18958 Net1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25448 Net1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NET1 VGNC VGNC:32010
Mus musculus NET1 MGD MGI:1927138
Macaca mulatta NET1 VGNC VGNC:75176
Felis catus NET1 VGNC VGNC:63779
Rattus norvegicus NET1 RGD RGD:1305034
Canis familiaris NET1 VGNC VGNC:43747
Others NET1 NCBI