NET1 Antibody
(Synonyms: ARHGEF8, NET1, Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8)NET1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to NET1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
NET1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to NET1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 67 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 67 kDa
Purified recombinant protein of human NET1
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NET1 acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_Specificity: Widely expressed.
Induction: By TGFB1. Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR). -
Isoforms & Post-Translational Modification
NET1 has 2 isoforms, Q7Z628-1: amino acid length is 596, molecular weight is 67740 Da (predicted); Q7Z628-2: amino acid length is 542, molecular weight is 61885 Da (predicted).NET1 存在 2 个异构体，Q7Z628-1：氨基酸个数为 596 个，分子量为 67740 Da (预测)；Q7Z628-2：氨基酸个数为 542 个，分子量为 61885 Da (预测)。
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Subunit
Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state.
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SwissProt ID
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Synonyms
ARHGEF8, NET1, Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8
Documentation
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