RPS6KA1 - ribosomal protein S6 kinase A1 Gene

Also Known as RSK; HU-1; RSK1; p90Rsk; MAPKAPK1; MAPKAPK1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6195

About RPS6KA1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,529,761-26,575,025 (from NCBI)

This gene has 20 transcripts (splice variants), 1 gene allele, 218 orthologues and 7 paralogues. Broad expression in small intestine (RPKM 31.6), duodenum (RPKM 29.3) and 21 other tissues.

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RPS6KA1 Products (5)

mRNA	Protein	Name
XM_024448871.2	XP_024304639.1	ribosomal protein S6 kinase alpha-1 isoform X2
XM_047427258.1	XP_047283214.1	ribosomal protein S6 kinase alpha-1 isoform X1
NM_001330441.2	NP_001317370.1	ribosomal protein S6 kinase alpha-1 isoform c
NM_002953.4	NP_002944.2	ribosomal protein S6 kinase alpha-1 isoform a
NM_001006665.2	NP_001006666.1	ribosomal protein S6 kinase alpha-1 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19470470	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10679322	GOA
enables protein serine/threonine/tyrosine kinase activity	IDA IDA: Inferred from direct assay	22797923	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	35772404	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11684016	GOA
involved in positive regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	10679322	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22065586	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	35772404	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KA1 Protein Structure

Pkinase

Pkinase_C

Pkinase

0
200
400
600
735 a.a.

Protein Preferred Names	Protein Names
ribosomal protein S6 kinase alpha-1	90 kDa ribosomal protein S6 kinase 1 MAP kinase-activated protein kinase 1a MAPK-activated protein kinase 1a MAPKAP kinase 1a MAPKAPK-1a RSK-1 S6K-alpha 1 dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1) p90-RSK 1 p90RSK1 p90S6K ribosomal S6 kinase 1 ribosomal protein S6 kinase, 90kDa, polypeptide 1

RPS6KA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPS6KA1	Q15418	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	35271311
Intra	RPS6KA1	Q15418	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	RPS6KA1	Q15418	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	RPS6KA1	Q15418	HSP90AB1	Homo sapiens	P08238	TAP	23455922
Intra	RPS6KA1	Q15418	SCRIB	Homo sapiens	Q14160	Pull Down	30126976
Intra	RPS6KA1	Q15418	S100B	Homo sapiens	P04271	FPS	31837246
Intra	RPS6KA1	Q15418	VASP	Homo sapiens	P50552	Protein Kinase Assay	21423205
Intra	RPS6KA1	Q15418	VASP	Homo sapiens	P50552	Anti Bait CoIP	21423205
Intra	RPS6KA1	Q15418	MAPK1	Homo sapiens	P28482	TAP	23455922
Intra	RPS6KA1	Q15418	MAPK1	Homo sapiens	P28482	X-Ray Diffraction	23519423
Cross	RPS6KA1	Q15418	yopM	Yersinia enterocolitica serotype O:8/biotype 1B	A1JU68	Anti Bait CoIP	25513777

Cross: Cross-species interaction Intra: Intraspecies interaction

RPS6KA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80315	RSK1 p90 Antibody (YA088)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P80848	Phospho-RSK1 p90 (Ser380) Antibody (YA158)	WB, ICC/IF, IP	Human, Rat, Mouse
HY-P80849	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157)	WB, IP	Human, Mouse, Rat
HY-P80849A	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P80886	RSK1 p90 Antibody (YA676)	WB, IP	Human, Mouse, Monkey
HY-P80886A	RSK1 p90 Antibody (YA676)(PBS only)	WB, IP	Human, Mouse, Monkey
HY-P86213	RSK1 p90 Antibody (YA5905) (YA5905)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86364	Phospho-RSK1 p90(Ser380) Antibody (YA6056) (YA6056)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86403	Phospho-RSK1 p90(Thr359/Ser363) Antibody (YA6095) (YA6095)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Coffin-Lowry Syndrome	CLS Mental Retardation With Osteocartilaginous Abnormalities Coffin Syndrome 1 Coffin Syndrome Dwarfism, Lean Spastic Type Lean Spastic Dwarfism Coffin Lowry Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123919	TL13-112	Inhibitor	98.01%	Unkown
HY-122582	TL13-12	Degrader	98.16%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		96.07%	Unkown
HY-136194	TL13-22	Inhibitor	99.71%	Unkown
HY-136195	TL13-110	Inhibitor	/	Unkown
HY-RS12248	RPS6KA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12249	Rps6ka1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12250	Rps6ka1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RPS6KA1	VGNC	VGNC:45738
Macaca mulatta	RPS6KA1	VGNC	VGNC:76927
Rattus norvegicus	RPS6KA1	RGD	RGD:620675
Felis catus	RPS6KA1	VGNC	VGNC:64754
Bos taurus	RPS6KA1	VGNC	VGNC:34140
Mus musculus	RPS6KA1	MGD	MGI:104558
Others	RPS6KA1	NCBI