1. PROTAC
    Protein Tyrosine Kinase/RTK
    Cell Cycle/DNA Damage
    Immunology/Inflammation
    MAPK/ERK Pathway
    Apoptosis
    Autophagy
  2. PROTACs
    Bcr-Abl
    CDK
    Salt-inducible Kinase (SIK)
    Cyclin G-associated Kinase (GAK)
    MAP4K
    MAPKAPK2 (MK2)
    Ferroptosis
    ULK
    LIM Kinase (LIMK)
  3. DB1113

DB1113 

Cat. No.: HY-148061 Purity: 99.28%
COA Handling Instructions

DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity.

For research use only. We do not sell to patients.

DB1113 Chemical Structure

DB1113 Chemical Structure

CAS No. : 2769753-53-7

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Description

DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

IC50 & Target

CDK4

 

CDK11B

 

MAP4K2

 

SIK2

 

SIK3

 

MAP4K5

 

HPK1

 

GLK/MAP4K3

 

ULK1

 

LIMK1

 

Molecular Weight

1144.31

Appearance

Solid

Formula

C59H68F3N13O6S

CAS No.
SMILES

O=C1N(C2=CC(NC(C3=CC(C(F)(F)F)=CC=C3)=O)=CC=C2C)CC4=CN=C(NC5=CN=C(N6CCN(CC6)CCCCC(N[[email protected]@H](C(C)(C)C)C(N7[[email protected]@H](C[[email protected]](C7)O)C(N[[email protected]](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=O)C=C5)N=C4N1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (52.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8739 mL 4.3694 mL 8.7389 mL
5 mM 0.1748 mL 0.8739 mL 1.7478 mL
10 mM 0.0874 mL 0.4369 mL 0.8739 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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