2. PROTAC Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Immunology/Inflammation MAPK/ERK Pathway Apoptosis Autophagy
  3. PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)
  4. DB1113

DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity.

For research use only. We do not sell to patients.

DB1113 Chemical Structure

DB1113 Chemical Structure

CAS No. : 2769753-53-7

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1 mg USD 340 In-stock
5 mg USD 850 In-stock
10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

DB1113 Related Antibodies

Top Publications Citing Use of Products

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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ULK1 ULK2

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LIMK1 LIMK2

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

IC50 & Target

CDK4

 

CDK11B

 

MAP4K2

 

SIK2

 

SIK3

 

MAP4K5

 

HPK1

 

GLK/MAP4K3

 

ULK1

 

LIMK1

 

Molecular Weight

1144.31

Formula

C59H68F3N13O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC(NC(C3=CC(C(F)(F)F)=CC=C3)=O)=CC=C2C)CC4=CN=C(NC5=CN=C(N6CCN(CC6)CCCCC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=O)C=C5)N=C4N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (52.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8739 mL 4.3694 mL 8.7389 mL
5 mM 0.1748 mL 0.8739 mL 1.7478 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8739 mL 4.3694 mL 8.7389 mL 21.8472 mL
5 mM 0.1748 mL 0.8739 mL 1.7478 mL 4.3694 mL
10 mM 0.0874 mL 0.4369 mL 0.8739 mL 2.1847 mL
15 mM 0.0583 mL 0.2913 mL 0.5826 mL 1.4565 mL
20 mM 0.0437 mL 0.2185 mL 0.4369 mL 1.0924 mL
25 mM 0.0350 mL 0.1748 mL 0.3496 mL 0.8739 mL
30 mM 0.0291 mL 0.1456 mL 0.2913 mL 0.7282 mL
40 mM 0.0218 mL 0.1092 mL 0.2185 mL 0.5462 mL
50 mM 0.0175 mL 0.0874 mL 0.1748 mL 0.4369 mL
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DB1113 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DB11132769753-53-7DB 1113DB-1113PROTACsBcr-AblCDKSalt-inducible Kinase (SIK)Cyclin G-associated Kinase (GAK)MAP4KMAPKAPK2 (MK2)FerroptosisULKLIM Kinase (LIMK)Cyclin dependent kinaseAuxilin 2MAPK Kinase Kinase KinaseMitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2Unc-51 like kinaseLIMKsbifunctionalprotein degradationkinasesaberrant kinase activityInhibitorinhibitorinhibit

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