LIMK1
LIMK1 is a kinase of the LISK family built from two N-terminal LIM domains, a PDZ domain and a catalytic kinase domain with mixed serine-threonine and tyrosine specificity. Activated by Rho-associated kinase (ROCK) and PAK downstream of the Rho and Rac GTPases, LIMK1 phosphorylates the actin-depolymerizing factor cofilin on a serine near its N-terminus, inactivating cofilin and stabilizing F-actin; this switch governs actin dynamics in growth cones, lamellipodia and stress fibers. LIMK1 lies within the Williams-Beuren syndrome deletion region and has been linked to cognitive phenotypes, while its overexpression in tumors promotes invasion and mitotic abnormalities. Recombinant LIMK1 supports cofilin phosphorylation assays and ROCK-pathway inhibitor screening.
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LIMK1 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
