ADRA1D - adrenoceptor alpha 1D Gene
Also Known as DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2
Species: Homo sapiens
About ADRA1D
This gene has 2 transcripts (splice variants), 196 orthologues and 18 paralogues. Biased expression in prostate (RPKM 2.3), spleen (RPKM 0.8) and 10 other tissues.
Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
ADRA1D Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000678.4 | NP_000669.1 | alpha-1D adrenergic receptor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
14645668 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16533813 | GOA |
ADRA1D Protein Structure
7tm_1: 7 transmembrane receptor (rhodopsin family) (113 - 402)
- 0
- 100
- 200
- 300
- 400
- 500
- 572 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
alpha-1D adrenergic receptor |
|
ADRA1D Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Cross
|
ADRA1D | P25100 | Snta1 | Mus musculus | Q61234 | 16533813 | |
|
Intra
|
ADRA1D | P25100 | SCRIB | Homo sapiens | Q14160 | 26617989 | |
|
Intra
|
ADRA1D | P25100 | SCRIB | Homo sapiens | Q14160 | 26617989 | |
|
Intra
|
ADRA1D | P25100 | SCRIB | Homo sapiens | Q14160 | 26617989 | |
|
Intra
|
ADRA1D | P25100 | SCRIB | Homo sapiens | Q14160 | 27382054 | |
|
Intra
|
ADRA1D | P25100 | SNTB2 | Homo sapiens | Q13425 | 26617989 | |
|
Intra
|
ADRA1D | P25100 | SNTB2 | Homo sapiens | Q13425 | 18468998 | |
|
Intra
|
ADRA1D | P25100 | SNTA1 | Homo sapiens | Q13424 | 26617989 | |
|
Intra
|
ADRA1D | P25100 | SNTB2 | Homo sapiens | Q13425 | 27382054 | |
|
Intra
|
ADRA1D | P25100 | SNTB2 | Homo sapiens | Q13425 | 21115837 | |
|
Intra
|
ADRA1D | P25100 | SNTA1 | Homo sapiens | Q13424 | 26617989 | |
|
Intra
|
ADRA1D | P25100 | SNTA1 | Homo sapiens | Q13424 | 26617989 | |
|
Intra
|
ADRA1D | P25100 | SNTB2 | Homo sapiens | Q13425 | 18468998 | |
|
Intra
|
ADRA1D | P25100 | SNTA1 | Homo sapiens | Q13424 | 18468998 | |
|
Intra
|
ADRA1D | P25100 | SNTA1 | Homo sapiens | Q13424 | 27382054 |
ADRA1D Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811140 | Alpha-1D Adrenergic Receptor Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ureterolithiasis |
|
|
| Perianal Hematoma |
|
|
| Gastroparesis |
|
|
| Prostatic Hypertrophy |
|
|
| Schizophrenia 19 |
|
|
| Impotence |
|
|
| Hypertension, Essential |
|
|
| Urethral Stricture |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | ADRA1D | RGD | RGD:62064 |
| Felis catus | ADRA1D | VGNC | VGNC:59655 |
| Canis familiaris | ADRA1D | VGNC | VGNC:37674 |
| Bos taurus | ADRA1D | VGNC | VGNC:25695 |
| Mus musculus | ADRA1D | MGD | MGI:106673 |
| Macaca mulatta | ADRA1D | VGNC | VGNC:107732 |
| Others | ADRA1D | NCBI |