1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. ADRA1D receptor agonist 1

ADRA1D receptor agonist 1 

Cat. No.: HY-135270
Handling Instructions

ADRA1D receptor agonist 1 (compound (R)-9S) is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM.

For research use only. We do not sell to patients.

ADRA1D receptor agonist 1 Chemical Structure

ADRA1D receptor agonist 1 Chemical Structure

CAS No. : 1191908-14-1

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ADRA1D receptor agonist 1 (compound (R)-9S) is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1].

IC50 & Target

Ki: 1.6 nM (α1D adrenoceptor)[1]

In Vitro

ADRA1D receptor agonist 1 shows low hERG inhibition[1].
ADRA1D receptor agonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ADRA1D receptor agonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat with bladder outlet obstruction (BOO)[1]
Dosage: 4.4 µg/kg
Administration: Intravenous injection
Result: Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.
Molecular Weight

337.20

Formula

C₁₅H₁₄Cl₂N₄O

CAS No.

1191908-14-1

SMILES

O=C(C1=CC(Cl)=CN([[email protected]@H](C2=CC=CC(C#N)=C2)C)C1=N)N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ADRA1D receptor agonist 1Adrenergic ReceptorBeta Receptorbladderoutletobstructionα(1D)-adrenoceptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ADRA1D receptor agonist 1
Cat. No.:
HY-135270
Quantity:
MCE Japan Authorized Agent: