APC - APC regulator of WNT signaling pathway Gene

Also Known as GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 324

About APC

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:112,707,498-112,846,239 (from NCBI)

This gene has 10 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 216 phenotypes. Ubiquitous expression in brain (RPKM 25.7), colon (RPKM 4.5) and 23 other tissues.

Summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in Other processes including cell migration and adhesion, transcriptional activation, and Apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]

APC Products (37)

mRNA	Protein	Name
NM_001354903.2	NP_001341832.1	adenomatous polyposis coli protein isoform j
NM_001354902.2	NP_001341831.1	adenomatous polyposis coli protein isoform i
NM_001407460.1	NP_001394389.1	adenomatous polyposis coli protein isoform j
NM_001407453.1	NP_001394382.1	adenomatous polyposis coli protein isoform h
NM_001354900.2	NP_001341829.1	adenomatous polyposis coli protein isoform g
NM_000038.6	NP_000029.2	adenomatous polyposis coli protein isoform b
NM_001354905.2	NP_001341834.1	adenomatous polyposis coli protein isoform l
NM_001407456.1	NP_001394385.1	adenomatous polyposis coli protein isoform q
NM_001407472.1	NP_001394401.1	adenomatous polyposis coli protein isoform s
NM_001407459.1	NP_001394388.1	adenomatous polyposis coli protein isoform j
NM_001407470.1	NP_001394399.1	adenomatous polyposis coli protein isoform m
NM_001354899.2	NP_001341828.1	adenomatous polyposis coli protein isoform f
NM_001127511.3	NP_001120983.2	adenomatous polyposis coli protein isoform a
NM_001407458.1	NP_001394387.1	adenomatous polyposis coli protein isoform j
NM_001354897.2	NP_001341826.1	adenomatous polyposis coli protein isoform d
NM_001354895.2	NP_001341824.1	adenomatous polyposis coli protein isoform b
NM_001407471.1	NP_001394400.1	adenomatous polyposis coli protein isoform s
NM_001407451.1	NP_001394380.1	adenomatous polyposis coli protein isoform o
NM_001407455.1	NP_001394384.1	adenomatous polyposis coli protein isoform q
NM_001407454.1	NP_001394383.1	adenomatous polyposis coli protein isoform q
NM_001354906.2	NP_001341835.1	adenomatous polyposis coli protein isoform m
NM_001407447.1	NP_001394376.1	adenomatous polyposis coli protein isoform c
NM_001354898.2	NP_001341827.1	adenomatous polyposis coli protein isoform e
NM_001354896.2	NP_001341825.1	adenomatous polyposis coli protein isoform c
NM_001354901.2	NP_001341830.1	adenomatous polyposis coli protein isoform h
NM_001354904.2	NP_001341833.1	adenomatous polyposis coli protein isoform k
NM_001407450.1	NP_001394379.1	adenomatous polyposis coli protein isoform b
NM_001407448.1	NP_001394377.1	adenomatous polyposis coli protein isoform c
NR_176365.1
NR_176366.1
NM_001407469.1	NP_001394398.1	adenomatous polyposis coli protein isoform r
NM_001127510.3	NP_001120982.1	adenomatous polyposis coli protein isoform b
NM_001407457.1	NP_001394386.1	adenomatous polyposis coli protein isoform q
NM_001407467.1	NP_001394396.1	adenomatous polyposis coli protein isoform r
NM_001407449.1	NP_001394378.1	adenomatous polyposis coli protein isoform c
NM_001407446.1	NP_001394375.1	adenomatous polyposis coli protein isoform n
NM_001407452.1	NP_001394381.1	adenomatous polyposis coli protein isoform p

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	EXP EXP: Inferred from Experiment	15327768	GOA
enables beta-catenin binding	IDA IDA: Inferred from direct assay	7806582	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	7890674	GOA
NOT enables cadherin binding	IDA IDA: Inferred from direct assay	7890674	GOA
enables dynein complex binding	IPI IPI: Inferred from physical interaction	28057765	GOA
enables gamma-catenin binding	IPI IPI: Inferred from physical interaction	7890674	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	11166179	GOA
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	19632184	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8638125	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	24130866	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8638126	GOA
enables protein kinase regulator activity	IDA IDA: Inferred from direct assay	11972058	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	18076571	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	14728717	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19151759	GOA
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28057765	GOA
acts upstream of or within mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	17570218	GOA
acts upstream of or within mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	17227893	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	10656683	GOA
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	12952940	GOA
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	21471006	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	10656683	GOA
involved in negative regulation of cell cycle G1/S phase transition	IDA IDA: Inferred from direct assay	8521819	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8521819	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8521819	GOA
involved in negative regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	11166179	GOA
acts upstream of or within negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	17192415	GOA
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17227893	GOA
acts upstream of or within positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17192415	GOA
acts upstream of or within positive regulation of protein catabolic process	IGI IGI: Inferred from genetic interaction	12952940	GOA
involved in positive regulation of protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	28057765	GOA
acts upstream of or within positive regulation of pseudopodium assembly	IMP IMP: Inferred from mutant phenotype	17192415	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	16188939	GOA
acts upstream of or within regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	17227893	GOA
involved in regulation of microtubule-based movement	IEP IEP: Inferred from expression pattern	28057765	GOA
involved in regulation of microtubule-based process	IMP IMP: Inferred from mutant phenotype	20937854	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with adherens junction	IDA IDA: Inferred from direct assay	16611247	GOA
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	8638126	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	18502210	GOA
part of catenin complex	IDA IDA: Inferred from direct assay	7806582	GOA
located in centrosome	IDA IDA: Inferred from direct assay	11283619	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11035805	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	11283619	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	19151759	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	12072559	GOA
colocalizes with microtubule	IDA IDA: Inferred from direct assay	28057765	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11035805	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18076571	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	16611247	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20937854	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	19151759	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APC Protein Structure

Suppressor_APC

Arm

APC_15aa

APC_r

SAMP

APC_r

SAMP

APC_r

SAMP

APC_basic

EB1_binding

0
500
1000
1500
2000
2500
2843 a.a.

Protein Preferred Names	Protein Names
adenomatous polyposis coli protein	APC, WNT signaling pathway regulator WNT signaling pathway regulator adenomatosis polyposis coli tumor suppressor adenomatous polyposis coli (APC) deleted in polyposis 2.5 epididymis secretory sperm binding protein protein phosphatase 1, regulatory subunit 46

APC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APC	P25054	SPATA13	Homo sapiens	Q96N96	Y2H	17599059
Intra	APC	P25054	SPATA13	Homo sapiens	Q96N96-1	IF	17145773
Intra	APC	P25054	SPATA13	Homo sapiens	Q96N96-1	Anti Tag CoIP	17145773
Intra	APC	P25054	SPATA13	Homo sapiens	Q96N96-1	Pull Down	17145773
Intra	APC	P25054	SPATA13	Homo sapiens	Q96N96-1	GDP/GTP Exchange	17145773
Intra	APC	P25054	ARHGEF4	Homo sapiens	Q9NR80-3	Pull Down	10947987
Intra	APC	P25054	ARHGEF4	Homo sapiens	Q9NR80-3	Y2H	10947987
Intra	APC	P25054	ARHGEF4	Homo sapiens	Q9NR80-3	Pull Down	17145773
Intra	APC	P25054	KHDRBS1	Homo sapiens	Q07666	ITC	22000517
Intra	APC	P25054	KHDRBS1	Homo sapiens	Q07666	X-Ray Diffraction	22000517
Intra	APC	P25054	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	APC	P25054	SCRIB	Homo sapiens	Q14160	CoIP	16611247
Intra	APC	P25054	SCRIB	Homo sapiens	Q14160	Pull Down	16611247
Cross	APC	P25054	Ctnnb1	Mus musculus	Q02248	ITC	16293619
Intra	APC	P25054	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	35271311
Intra	APC	P25054	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	26496610
Intra	APC	P25054	CTNNB1	Homo sapiens	P35222	X-Ray Diffraction	15327768
Intra	APC	P25054	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	22682247
Intra	APC	P25054	CTNNB1	Homo sapiens	P35222	Pull Down	16212417
Intra	APC	P25054	AMER1	Homo sapiens	Q5JTC6	Anti Tag CoIP	26496610
Intra	APC	P25054	CTNNA1	Homo sapiens	P35221	Anti Tag CoIP	26496610
Intra	APC	P25054	CTNNA1	Homo sapiens	P35221	Y2H Pooling	20936779
Intra	APC	P25054	JUP	Homo sapiens	P14923	Anti Tag CoIP	26496610
Intra	APC	P25054	DVL1	Homo sapiens	O14640	Anti Bait CoIP	20224554
Intra	APC	P25054	DVL1	Homo sapiens	O14640	Anti Tag CoIP	11425858
Intra	APC	P25054	DVL2	Homo sapiens	O14641	Anti Tag CoIP	26496610
Intra	APC	P25054	DVL2	Homo sapiens	O14641	Anti Bait CoIP	20224554
Intra	APC	P25054	CSNK1E	Homo sapiens	P49674	Protein Kinase Assay	11425858
Intra	APC	P25054	CSNK1E	Homo sapiens	P49674	Protein Kinase Assay	17218255
Intra	APC	P25054	CSNK1E	Homo sapiens	P49674	PLA	25241761
Intra	APC	P25054	CSNK1E	Homo sapiens	P49674	Anti Tag CoIP	11425858
Intra	APC	P25054	CDC42	Homo sapiens	P60953	GDP/GTP Exchange	17145773
Intra	APC	P25054	CDC42	Homo sapiens	P60953	Confocal	21311754
Intra	APC	P25054	AMER3	Homo sapiens	Q8N944	Anti Tag CoIP	24251807

Cross: Cross-species interaction Intra: Intraspecies interaction

APC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80016	APC Antibody (YA617)	WB, ICC/IF, IP	Human, Mouse

Related Diseases

Diseases	Alias
Tumor Predisposition Syndrome	TPDS Tumor Predisposition
Thoracic Cancer	Thoracic Tumor Thorax Cancer Thorax Neoplasm Tumor Of Thorax Thoracic Neoplasms
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Duodenal Benign Neoplasm	Neoplasm Of Duodenum Neoplasm Of The Duodenum Cancer Of Duodenum
Fibromatosis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Juvenile Polyposis Syndrome	JPS Juvenile Intestinal Polyposis Jip Pji Juvenile Gastrointestinal Polyposis Juvenile Polyposis Polyposis, Juvenile Intestinal Polyposis, Familial, Of Entire Gastrointestinal Tract Polyposis Familial Of Entire Gastrointestinal Tract Polyposis Juvenile Intestinal Polyposis Syndrome, Juvenile
Pseudohypoparathyroidism	Familial Pseudohypoparathyroidism Parathyroid Hormone Resistant Hypoparathyroidism Php - [Pseudohypoparathyroidism] Constitutional Chronic Hypocalcaemia
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a	Multiple Pterygium Syndrome, Autosomal Dominant CPSFS1A Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a Autosomal Dominant Disease Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a Cpskf1a Pterygium Syndrome, Multiple Autosomal Dominant Arthrogryposis, Distal, Type 8, Formerly Da8, Formerly Autosomal Dominant Multiple Pterygium Syndrome Distal Arthrogryposis Type 8 Arthrogryposis, Distal, Type 8 Da8 Pterygium Syndrome, Multiple, Autosomal Dominant Autosomal Dominant Disorder
Urinary System Disease	Abnormality Of The Urinary System Non-Neoplastic Urinary Tract Disease Urinary Tract Disease Urinary Tract Diseases Urinary Tract Anomaly Urologic Diseases Non-Neoplastic Urinary System Disorder Congenital Malformation Of The Urinary System
Lymphangioma	Lymphatic Malformation Lymphatic Malformations Benign Lymphangioma Congenital Lymphangioma Lymphangiomas
Ampulla Of Vater Benign Neoplasm	Tumor Of The Ampulla Of Vater
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Cardiovascular Organ Benign Neoplasm
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Large Intestine Cancer
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Immune System Disease	Abnormality Of The Immune System Immune System And Disorders Immune System Diseases
Gastric Adenocarcinoma	Adenocarcinoma Of Stomach Stomach Adenocarcinoma Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Of Unspecified Site Diffuse Type Adenocarcinoma Of Unspecified Site
Mismatch Repair Cancer Syndrome 1	Turcot Syndrome Constitutional Mismatch Repair Deficiency Syndrome Mismatch Repair Deficiency Mmr Deficiency MMRCS1 Cmmrds Childhood Cancer Syndrome Brain Tumor-Polyposis Syndrome 1 Btps1 Btp1 Syndrome Mismatch Repair Cancer Syndrome Childhood Cancer Brain Tumor-Polyposis Syndrome Cns Tumors With Familial Polyposis Of The Colon Glioma-Polyposis Syndrome Mmrcs Malignant Tumors Of The Central Nervous System Associated With Familial Polyposis Of The Colon Biallelic Mismatch Repair Deficiency Syndrome Bmmrd Cmmr-D Syndrome
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Male Reproductive System Disease	Genital Diseases, Male Disorder Of Male Reproductive System
Autosomal Genetic Disease	Autosomal Hereditary Disorder
Anus Disease	Anal Fissure Ulcer Of Anus Anus Diseases Anal Disease Anal Fissure And Fistula Anal Ulcer Fissure In Ano Nontraumatic Tear Of Anus Solitary Anal Ulcer Abnormality Of The Anus Anal Disorders Ulcer Of Anus And Rectum Solitary Ulcer Of Anus Stercoral Ulcer Of Anus
Endocrine Gland Cancer	Endocrine Neoplasm Malignant Neoplasm Of Endocrine Gland Endocrine Gland Neoplasms Endocrine Tumor Malignant Endocrine Tumor Malignant Tumour Of Endocrine Gland Neoplasm Of Endocrine Gland Neoplasm Of Endocrine System Neoplasm Of The Endocrine System Carcinoma Of Endocrine Gland
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Desmoid Disease, Hereditary	Fif DESMD Hereditary Desmoid Disease Familial Infiltrative Fibromatosis Fibromatosis, Familial Infiltrative Fibromatosis, Aggressive
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Cell Type Benign Neoplasm
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Gastrointestinal System Benign Neoplasm
Retinal Disease	Retinal Diseases Retinal Disorder Retinal Disorders
Lymphatic System Disease	Lymphatic Diseases Adenopathy Disease Of Lympoid System Disorder Of Lymph Node And Lymphatics Disorder Of Lymphatic System Disorder Of Lymphoid System Lymphangiopathy Lymphatic Disease Lymphatic Disorder Lympoid System Disease Abnormality Of The Lymphatic System
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Hamartomatous Intestinal Polyposis Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Villous Adenoma	Adenoma Villous Adenoma, Villous
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Periampullary Adenoma
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Malignant Ovarian Surface Epithelial-Stromal Neoplasm	Malignant Ovarian Surface Epithelial-Stromal Tumor
Duodenum Adenoma
Colonic Disease	Colonic Diseases Colon Disorder
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Mccune-Albright Syndrome	Mass Syndrome Polyostotic Fibrous Dysplasia MAS Fibrous Dysplasia Of Bone Albright Syndrome Mass Phenotype Overlap Connective Tissue Disease Mccune Albright Syndrome Osteitis Fibrosa Disseminata OCTD Albright'S Disease Pfd Pofd Albright'S Syndrome Mccune-Albright Syndrome, Somatic, Mosaic Albright'S Disease Of Bone Albright'S Syndrome With Precocious Puberty Albright-Mccune-Sternberg Syndrome Albright-Sternberg Syndrome Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty Gonadotropin-Independent Female-Limited Sexual Precocity Fibrous Dysplasia Polyostotic Fibrous Dysplasia, Polyostotic
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Germinoma
Rectum Cancer	Malignant Neoplasm Of Rectum Rectal Cancer Cancer Of Rectum Carcinoma Of Rectum Carcinoma Of The Rectum Malignant Rectal Tumor Malignant Rectum Tumor Malignant Tumor Of Rectum Rectal Carcinoma Rectal Cancers Cancer, Rectal
Fibrous Dysplasia	Fibrous Dysplasia Of Bone
Gastric Adenocarcinoma And Proximal Polyposis Of The Stomach	Polyposis, Gastric GAPPS Polyposis Of Gastric Fundus Without Polyposis Coli Fundic Gland Polyposis Familial Fundic Gland Polyposis With Gastric Cancer Gastric Polyposis
Epidermoid Cysts	Epidermoid Cyst Sebaceous Cyst Epidermal Inclusion Cyst Epidermal Cyst
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Large Intestine Adenoma	Adenoma Of Large Intestine
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Familial Polyposis Coli Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Colon Adenoma	Adenomatous Polyp Of Colon
Malignant Astrocytoma	Astrocytic Tumor Astrocytoma Of Brain Astrocytoma Of Cerebrum Astroglioma Cerebral Astrocytoma Astrocytoma
Craniopharyngioma	Neoplasm Of Rathke'S Pouch Adamantinomatous Tumor Craniopharyngeal Duct Tumor Dysodontogenic Epithelial Tumor Rathke'S Pouch Tumor
Oropharynx Cancer	Oropharyngeal Cancer Oropharyngeal Carcinoma Malignant Neoplasm Of Oropharynx Malignant Oropharyngeal Tumor Malignant Tumor Of Oropharynx Malignant Tumour Of Mesopharynx Oropharyngeal Cancer, Adult Cancer Of The Oropharynx
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Barrett Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma Barrett'S Esophagus Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Hemorrhoid	Hemorrhoids Hemorrhoidal Disease Rectal Diseases Piles Unspecified Haemorrhoids Without Complication
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Reproductive System Disease	Abnormality Of The Genital System Genital System Disease Reproductive System Disorder
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Female Reproductive System Disease	Genital Diseases, Female Female Reproductive System Disorder
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Syndactyly, Type I Sd1 Zygodactyly Syndactyly, Type 1, With Or Without Craniosynostosis Non-Syndromic Syndactyly Symphalangism Symphalangy Webbing Of Digits Syndactyly, Type 1
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Gastrointestinal Adenoma	Gi Adenoma Digestive System Adenoma
Lymphatic System Cancer
Sensory System Disease
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Polyposis Syndrome, Hereditary Mixed, 1	HMPS1 Colorectal Adenoma And Carcinoma 1 Crac1 Colorectal Cancer 4 Chromosome 15q13-Q14 Duplication Syndrome, 40-Kb Colorectal Cancer, Susceptibility To, 4 Hereditary Mixed Polyposis Syndrome 1 Polyposis Syndrome, Hereditary Mixed 1 CRCS4 Susceptibility To Colorectal Cancer On Chromosome 15 Polyposis Syndrome, Mixed Hereditary 1 Adenomatous Polyps
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Apc-Associated Polyposis Conditions
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Malignant Exocrine Pancreas Neoplasm	Malignant Neoplasm Of The Exocrine Pancreas Malignant Tumor Of Exocrine Pancreas Malignant Tumour Of Exocrine Pancreas
Familial Adenomatous Polyposis 1	Gardner Syndrome Brain Tumor-Polyposis Syndrome 2 Familial Polyposis Of The Colon Adenomatous Polyposis Coli FAP1 Adenomatous Polyposis Of The Colon Apc Fpc Gardner'S Syndrome Polyposis, Adenomatous Intestinal Adenoma, Periampullary, Somatic Intestinal Polyposis, Osteomas, Sebaceous Cysts Polyposis Coli And Multiple Hard And Soft Tissue Tumors Apc-Related Attenuated Familial Adenomatous Polyposis Apc-Related Afap Apc-Related Attenuated Fap Apc-Related Attenuated Familial Polyposis Coli Turcot Syndrome With Polyposis Gardners Syndrome Adenomatous Polyposis Coli, Susceptibility To Adenomatous Polyposis, Familial, Type 1
Hepatocellular Adenoma	Adenoma Hepatocellular
Rectum Adenocarcinoma	Rectal Adenocarcinoma Adenocarcinoma Of Rectum
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Intestinal Benign Neoplasm	Intestinal Neoplasms Intestinal Tumors Intestine Growth Neoplasm Of Intestinal Tract
Bile Duct Disease	Bile Duct Diseases Bile Duct Disorder Disorder Of Bile Duct
Integumentary System Disease
Gastrointestinal System Disease	Gastrointestinal Disease Gastrointestinal Diseases Alimentary System Disease Digestive System Disorder Gastroenteropathy Gastrointestinal Disorder Git Disease Digestive System Diseases Gastrointestinal Disorders Digestive System Disease Digestive System Disorders
Colorectal Adenoma	Colorectal Adenomas Adenoma Of Large Intestine
Hepatoblastoma
Familial Adenomatous Polyposis Due To 5q22.2 Microdeletion	Colorectal Adenomatous Polyposis Due To Monosomy 5q22.2 Fap Due To Monosomy 5q22.2 Familial Adenomatous Polyposis Due To Del(5)(Q22.2) Familial Adenomatous Polyposis Due To Monosomy 5q22.2 Familial Polyposis Coli Due To Monosomy 5q22.2
Gastrointestinal System Cancer	Digestive System Neoplasms Gastrointestinal Neoplasms Digestive System Cancer Gastrointestinal Tract Cancer Gi Tumor Digestive System Neoplasm Digestive System Carcinoma Malignant Neoplasm Of Gastrointestinal Tract Cancer Of Digestive System
Colorectal Cancer, Hereditary Nonpolyposis, Type 5	HNPCC5 Hereditary Nonpolyposis Colorectal Cancer Type 5 Hereditary Non-Polyposis Colorectal Cancer 5 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 5
Ocular Cancer	Eye Carcinoma Eye Neoplasm Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Anal Gland Neoplasm	Anal Gland Neoplasms
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Cenani-Lenz Syndactyly Syndrome	Syndactyly Type 7 Cenani Syndactylism Cenani-Lenz Syndactyly CLSS Syndactyly Cenani Lenz Type Cenani-Lenz Syndrome Syndactyly, Type Vii Cenani-Lenz Type Syndactyly Cenani Syndactyly Syndactyly Type Vii
Intestinal Disease	Intestinal Diseases
Central Nervous System Cancer	Central Nervous System Tumor Central Nervous System Tumors Cns Neoplasm Malignant Neoplasm Of Central Nervous System Malignant Tumor Of Cns Neoplasm Of Central Nervous System Malignant Neoplasm Of The Central Nervous System Neoplasm Of The Central Nervous System Central Nervous System Neoplasms Central Nervous System Neoplasm
Small Intestine Benign Neoplasm	Neoplasm Of Small Intestine Small Intestinal Neoplasm Neoplasm Of The Small Intestine Small Bowel Cancer Small Intestine Cancer Malignant Neoplasm Of Small Intestine, Unspecified Malignant Tumour Of Small Bowel Malignant Tumour Of Small Intestine Primary Malignant Neoplasm Of Meckel Diverticulum
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112968	Human protein C		/	Unkown

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124955	proTAME	Inhibitor	98.20%	Unkown
HY-110287	Apcin	Inhibitor	99.62%	Unkown
HY-13255	TAME	Inhibitor	99.51%	Unkown
HY-130841	Apcin-A	Inhibitor	98.0%	Unkown
HY-P1918	Activated Protein C (390-404), human		98.74%	Unkown
HY-13255A	TAME hydrochloride	Inhibitor	98.31%	Unkown
HY-122142A	Pyr-Pro-Arg-pNA (hydrochloride)	Substrate	99.24%	Unkown
HY-182052	Ferroptosis inducer-16	Inhibitor	/	Unkown
HY-112968A	Bovine Protein C		/	Unkown
HY-122142	Pyr-Pro-Arg-pNA	Substrate	/	Unkown
HY-126016	MAI-400	Inhibitor	/	Unkown
HY-P1918A	Activated Protein C (390-404), human TFA		/	Unkown
HY-116473	CFM-1	Antagonist	/	Unkown
HY-179012	CDC20/HSP90-IN-1	Inhibitor	/	Unkown
HY-172401	CDC20-IN-2	Inhibitor	/	Unkown
HY-W614725	Apcin-A monohydrochloride	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992193	Anti-B7-H7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	APC	RGD	RGD:2123
Felis catus	APC	VGNC	VGNC:99681
Macaca mulatta	APC	VGNC	VGNC:84282
Canis familiaris	APC	VGNC	VGNC:99669
Mus musculus	APC	MGD	MGI:88039
Bos taurus	APC	VGNC	VGNC:55103
Others	APC	NCBI