1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Ser/Thr Protease
    APC
  3. TAME hydrochloride

TAME hydrochloride 

Cat. No.: HY-13255A Purity: 99.10%
Handling Instructions

TAME hydrochloride is a serine protease inhibitor and can be also utilized as a substrate for the serine proteases trypsin, plasmin, and thrombin. TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which binds to the APC and prevents its activation by Cdc20 and Cdh1.

For research use only. We do not sell to patients.

TAME hydrochloride Chemical Structure

TAME hydrochloride Chemical Structure

CAS No. : 1784-03-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 59 In-stock
Estimated Time of Arrival: December 31
50 mg USD 54 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TAME hydrochloride:

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Description

TAME hydrochloride is a serine protease inhibitor and can be also utilized as a substrate for the serine proteases trypsin, plasmin, and thrombin[1][2][3]. TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which binds to the APC and prevents its activation by Cdc20 and Cdh1[4].

IC50 & Target

Serine protease[2]
Anaphase-promoting complex (APC)[4]

Molecular Weight

378.87

Formula

C₁₄H₂₃ClN₄O₄S

CAS No.

1784-03-8

SMILES

CC1=CC=C(C=C1)S(N[[email protected]](C(OC)=O)CCCNC(N)=N)(=O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 155 mg/mL (409.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6394 mL 13.1971 mL 26.3943 mL
5 mM 0.5279 mL 2.6394 mL 5.2789 mL
10 mM 0.2639 mL 1.3197 mL 2.6394 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (6.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.58 mg/mL (6.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.58 mg/mL (6.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
TAME hydrochloride
Cat. No.:
HY-13255A
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