1784-03-8
1784-03-8
Chemical Structure
TAME hydrochloride
- CAS No.: 1784-03-8
- Formula:C14H23ClN4O4S
- Molecular Weight:378.87
IUPAC Name: methyl tosyl-L-argininate hydrochloride
InChIKey: JIQFFACVQXXHMY-YDALLXLXSA-N
SMILES: CC1=CC=C(C=C1)S(N[C@H](C(OC)=O)CCCNC(N)=N)(=O)=O.[H]Cl
Biological Activity: TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TAME hydrochloride | 98.14% | TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-13255TAME -
Similarity Score 0.89
HY-W009144Tosyl-L-arginine -
Similarity Score 0.71
HY-112716N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride -
Similarity Score 0.71
HY-137038N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride -
Similarity Score 0.67
HY-B0401ATolbutamide sodium -
Similarity Score 0.66
HY-B0401RTolbutamide (Standard) -
Similarity Score 0.65
HY-W030771((4-(tert-Butyl)phenyl)sulfonyl)methionine -
Similarity Score 0.62
HY-W010913(S)-2-((tert-Butoxycarbonyl)amino)-5-(3-tosylguanidino)pentanoic acid -
Similarity Score 0.62
HY-W008694N-Benzoyl-L-arginine ethyl ester hydrochloride -
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References
- [1]. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95. [Content Brief]
- [2]. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8(4):383-92. [Content Brief]
