Tolbutamide sodium
Based on 10 publication(s) in Google Scholar
Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus.
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- CAS. Nr.: 473-41-6
- Formel: C12H18N2NaO3S
- Molecular Weight:293.34
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Tolbutamide sodium
More- Cell Stem Cell. 2025 Apr 3;32(4):547-563.e7. [Abstract]
- Acta Pharm Sin B. 2024 Aug;14(8):3493-3512. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Int J Biol Macromol. 2026 Mar:352:151224. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Cancer Cell Int. 2023 Jan 31;23(1):14. [Abstract]
- Biology (Basel). 2025 Jul 20;14(7):889. [Abstract]
- AAPS J. 2021 Jun 28;23(4):91. [Abstract]
- Egypt J Neurosurg. 2026 Jan 8;41(1):4.
- medRxiv. 2024 Jul 23.
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Biologische Aktivität
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 473-41-6
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Molecular Weight 293.34
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Formel C12H18N2NaO3S
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SMILES
O=S(C1=CC=C(C)C=C1)(NC(NCCCC)=O)=O.[Na]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (10)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds. [Abstract]2025 Apr 3;32(4):547-563.e7. PMID: 39999846 -
Acta Pharm Sin B
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis. [Abstract]2024 Aug;14(8):3493-3512. PMID: 39220878 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Cancer Cell Int
In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer. [Abstract]2023 Jan 31;23(1):14. PMID: 36717845 -
Biology (Basel)
Germination Enhances Phytochemical Profiles of Perilla Seeds and Promotes Hair Growth via 5α-Reductase Inhibition and Growth Factor Pathways. [Abstract]2025 Jul 20;14(7):889. PMID: 40723446 -
AAPS J
Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization. [Abstract]2021 Jun 28;23(4):91. PMID: 34181150 -
Tolbutamide sodium purchased from MedChemExpress. Usage Cited in: Egypt J Neurosurg. 2026 Jan 8;41(1):4.
Perforated cell recording of GT1-7 cells incubated in bath solution supplemented 2.5 mM glucose before and after perfusion of vehicle (top trace) or 10 nM leptin (bottom trace). After the membrane potential stabilized, 300 µM tolbutamide (tolb) was added to block KATP currents.
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Reinheit & Dokumentation
Verweise
[1]. Trube G, et al. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch. 1986 Nov;407(5):493-9. [Content Brief]
[2]. Efanova IB, et al. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem. 1998 Dec 11;273(50):33501-7. [Content Brief]
Calculators
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