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Cat. No.: HY-116473

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CFM-1

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells.

For research use only. We do not sell to patients.

CAS No.: 1380448-60-1
Formula: C₁₂H₇BrN₂O₂S₂
Molecular Weight:355.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CFM-1 Chemical Structure

CAS No.: 1380448-60-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Daoy	IC₅₀	8.12 μg/mL Compound: CFM-1	Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
HeLa	IC₅₀	13.5 μg/mL Compound: CFM-1	Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
Huh-7	IC₅₀	8.18 μg/mL Compound: CFM-1	Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
MDA-MB-231	IC₅₀	19.7 μg/mL Compound: CFM-1	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]

Chemical Information

CAS No. 1380448-60-1
Molecular Weight 355.23
Formula C₁₂H₇BrN₂O₂S₂
SMILES

O=C1NC2=C(C=C(Br)C=C2C)/C1=C(SC(N3)=S)\C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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