AMER3 - APC membrane recruitment protein 3 Gene

Also Known as FAM123C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 205147

About AMER3

This gene has 4 transcripts (splice variants), 106 orthologues and 2 paralogues. Biased expression in brain (RPKM 2.4), stomach (RPKM 0.3) and 3 other tissues.

Summary

Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AMER3 Products (4)

mRNA	Protein	Name
NM_001105193.2	NP_001098663.1	APC membrane recruitment protein 3
NM_001105194.2	NP_001098664.1	APC membrane recruitment protein 3
NM_001105195.2	NP_001098665.1	APC membrane recruitment protein 3
NM_152698.3	NP_689911.2	APC membrane recruitment protein 3

AMER3 Protein Structure

WTX

0
200
400
600
800
861 a.a.

Protein Preferred Names	Protein Names
APC membrane recruitment protein 3	family with sequence similarity 123C

AMER3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AMER3	Q8N944	AXIN2	Homo sapiens	Q9Y2T1	Anti Tag CoIP	24251807
Intra	AMER3	Q8N944	AXIN2	Homo sapiens	Q9Y2T1	Anti Bait CoIP	24251807
Intra	AMER3	Q8N944	AMER1	Homo sapiens	Q5JTC6	Anti Bait CoIP	24251807
Intra	AMER3	Q8N944	APC	Homo sapiens	P25054	Anti Tag CoIP	24251807
Intra	AMER3	Q8N944	APC	Homo sapiens	P25054	Anti Bait CoIP	24251807
Intra	AMER3	Q8N944	APC	Homo sapiens	P25054	IF	24251807
Intra	AMER3	Q8N944	APC	Homo sapiens	P25054	Y2H	24251807
Cross	AMER3	Q8N944	Axin2	Mus musculus	O88566	Anti Tag CoIP	24251807

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Tracheoesophageal Fistula With Or Without Esophageal Atresia	Esophageal Atresia With Or Without Tracheoesophageal Fistula Esophageal Atresia
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Esophageal Atresia/Tracheoesophageal Fistula	Esophageal Atresia And/Or Tracheoesophageal Fistula Tracheoesophageal Fistula With Or Without Esohageal Atresia Esophageal Atresia / Tracheoesophageal Fistula Ea/Tef Esophageal Atresia With Tracheoesophageal Fistula Esophageal Atresia With Or Without Tracheoesophageal Fistula
Osteopathia Striata With Cranial Sclerosis	Hyperostosis Generalisata With Striations Robinow-Unger Syndrome OSCS Osteopathia Striata Cranial Sclerosis Osteopathia Striata-Cranial Sclerosis Syndrome Horan-Beighton Syndrome Os-Cs Osteopathia Striata - Cranial Sclerosis Voorhoeve Disease Osc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00651	AMER3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AMER3	VGNC	VGNC:25862
Rattus norvegicus	AMER3	RGD	RGD:1560420
Canis familiaris	AMER3	VGNC	VGNC:58289
Macaca mulatta	AMER3	VGNC	VGNC:69713
Mus musculus	AMER3	MGD	MGI:3026939
Others	AMER3	NCBI