CDC20/HSP90-IN-1
CDC20/HSP90-IN-1 (Compound 2b) is a Cdc20/Hsp90 inhibitor with a Kd of 16.2 μM for Cdc20 and a Kd of 0.241 μM for Hsp90α. CDC20/HSP90-IN-1 exerts potent antitumor activity through reducing p53-mediated Cdc20, upregulating Bim, downregulating Cyclin B1 expression, and disturbing B-Raf and AKT pathways via destroying Hsp90 chaperone function. CDC20/HSP90-IN-1 overcomes Vemurafenib (HY-12057)-induced resistant melanoma.
For research use only. We do not sell to patients.
- Formula: C33H36Cl4N12O5
- Molecular Weight:822.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK1/cyclinB1 |
B-Raf |
HSP90α 0.241 μM (Kd) |
Chemical Information
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Molecular Weight 822.53
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Formula C33H36Cl4N12O5
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SMILES
O=C(NC(C(Cl)(Cl)Cl)NC1=NC=CC=N1)OCCOCCOCC2=CN(N=N2)CCC#CC3=CN(C4=NC(N)=NC(Cl)=C43)CC5=C(C(OC)=C(C=N5)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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