CDC20/HSP90-IN-1
CDC20/HSP90-IN-1 (Compound 2b) is a Cdc20/Hsp90 inhibitor with a Kd of 16.2 μM for Cdc20 and a Kd of 0.241 μM for Hsp90α. CDC20/HSP90-IN-1 exerts potent antitumor activity through reducing p53-mediated Cdc20, upregulating Bim, downregulating Cyclin B1 expression, and disturbing B-Raf and AKT pathways via destroying Hsp90 chaperone function. CDC20/HSP90-IN-1 overcomes Vemurafenib (HY-12057)-induced resistant melanoma.
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- Formule: C33H36Cl4N12O5
- Masse moléculaire:822.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CDK1/cyclinB1 |
B-Raf |
HSP90α 0.241 μM (Kd) |
Chemical Information
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Masse moléculaire 822.53
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Formule C33H36Cl4N12O5
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SMILES
O=C(NC(C(Cl)(Cl)Cl)NC1=NC=CC=N1)OCCOCCOCC2=CN(N=N2)CCC#CC3=CN(C4=NC(N)=NC(Cl)=C43)CC5=C(C(OC)=C(C=N5)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDC20/HSP90-IN-1 Related Classifications
HY-179012 Related Classifications
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