Pyr-Pro-Arg-pNA
Pyr-Pro-Arg-pNA (S-2366) is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein.
For research use only. We do not sell to patients.
- CAS No.: 72194-57-1
- Formula: C22H30N8O6
- Molecular Weight:502.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Pyr-Pro-Arg-pNA (0-1.5 mM) is hydrolyzed by purified human FXIa and FXIa-LC with Km values of 225 μM and 357 μM[1].
Pyr-Pro-Arg-pNA noncompetitively inhibits human FXIa-mediated FIX activation with a Ki of 425 μM and human FXIa-LC-mediated FIX activation with a Ki of 420 μM, without altering the Km values for FIX binding to either enzyme[1].
Pyr-Pro-Arg-pNA can be hydrolyzed by purified recombinant murine activated protein C with essentially identical kinetic activity to purified human activated protein C[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 72194-57-1
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Molecular Weight 502.52
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Formula C22H30N8O6
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SMILES
O=C([C@@H]1CCC(N1)=O)N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C(C=C3)[N+]([O-])=O)=O)=O
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Synonyms
S-2366
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sinha D, et al. Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation. Biochemistry. 2007;46(34):9830-9839. [Content Brief]
[3]. Fernández JA, et al. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003 May-Jun;30(3):271-6. [Content Brief]
[4]. Briseid K, et al. Part of purified human plasma kallikrein removed together with a remaining IgG fraction--immunoblot experiments and functional tests. Scand J Clin Lab Invest. 2002;62(1):21-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pyr-Pro-Arg-pNA Related Classifications
HY-122142 Related Classifications
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