2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Others
  3. APC Factor XI Biochemical Assay Reagents
  4. Pyr-​Pro-​Arg-​pNA hydrochloride

Pyr-​Pro-​Arg-​pNA hydrochloride  (Synonyms: S-2366 hydrochloride)

Cat. No.: HY-122142A Purity: 99.24%
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Pyr-Pro-Arg-pNA (S2366) hydrochloride is a chromogenic peptide substrate for Factor XI and Activated protein C (APC). Pyr-Pro-Arg-pNA hydrochloride can induce noncompetitive inhibition of factor XI activation through occupancy of the active site of the factor XIa-light chain. Pyr-Pro-Arg-pNA hydrochloride can be used for measurement of APC amidolytic activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Pyr-​Pro-​Arg-​pNA hydrochloride

Pyr-​Pro-​Arg-​pNA hydrochloride Chemical Structure

CAS No. : 127428-47-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Pyr-​Pro-​Arg-​pNA hydrochloride:

Pyr-​Pro-​Arg-​pNA hydrochloride Related Antibodies

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Description

Pyr-Pro-Arg-pNA (S2366) hydrochloride is a chromogenic peptide substrate for Factor XI and Activated protein C (APC). Pyr-Pro-Arg-pNA hydrochloride can induce noncompetitive inhibition of factor XI activation through occupancy of the active site of the factor XIa-light chain. Pyr-Pro-Arg-pNA hydrochloride can be used for measurement of APC amidolytic activity[1][2].

Molecular Weight

538.98

Formula

C22H31ClN8O6
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (185.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8554 mL 9.2768 mL 18.5536 mL
5 mM 0.3711 mL 1.8554 mL 3.7107 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8554 mL 9.2768 mL 18.5536 mL 46.3839 mL
5 mM 0.3711 mL 1.8554 mL 3.7107 mL 9.2768 mL
10 mM 0.1855 mL 0.9277 mL 1.8554 mL 4.6384 mL
15 mM 0.1237 mL 0.6185 mL 1.2369 mL 3.0923 mL
20 mM 0.0928 mL 0.4638 mL 0.9277 mL 2.3192 mL
25 mM 0.0742 mL 0.3711 mL 0.7421 mL 1.8554 mL
30 mM 0.0618 mL 0.3092 mL 0.6185 mL 1.5461 mL
40 mM 0.0464 mL 0.2319 mL 0.4638 mL 1.1596 mL
50 mM 0.0371 mL 0.1855 mL 0.3711 mL 0.9277 mL
60 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.7731 mL
80 mM 0.0232 mL 0.1160 mL 0.2319 mL 0.5798 mL
100 mM 0.0186 mL 0.0928 mL 0.1855 mL 0.4638 mL
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Pyr-​Pro-​Arg-​pNA hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyr-​Pro-​Arg-​pNA127428-47-1S-2366S2366S 2366APCFactor XIBiochemical Assay ReagentsAnaphase promoting complexChromogenic peptide substrateFXINoncompetitive inhibitionAmidolyticInhibitorinhibitorinhibit

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