DVL2 - dishevelled segment polarity protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1856

About DVL2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,225,342-7,234,517 (from NCBI)

This gene has 15 transcripts (splice variants), 195 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 14.8), endometrium (RPKM 11.4) and 25 other tissues.

Summary

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

DVL2 Products (1)

mRNA	Protein	Name
NM_004422.3	NP_004413.1	segment polarity protein dishevelled homolog DVL-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	19388021	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644691	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway, planar cell polarity pathway	IDA IDA: Inferred from direct assay	12805222	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17593335	GOA
involved in non-canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19137009	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17593335	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	19137009	GOA
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	17593335	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20137080	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12805222	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11742073	GOA
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18787224	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9192851	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	23209302	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DVL2 Protein Structure

DIX

Dishevelled

PDZ

DEP

Dsh_C

0
200
400
600
736 a.a.

Protein Preferred Names	Protein Names
segment polarity protein dishevelled homolog DVL-2	dishevelled 2 (homologous to Drosophila dsh)

DVL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DVL2	O14641	TLE5	Homo sapiens	Q08117-2	BFG-2H	27107012
Cross	DVL2	O14641	Smurf2	Mus musculus	A2A5Z6	Anti Tag CoIP	19379695
Cross	DVL2	O14641	Smurf2	Mus musculus	A2A5Z6	TAP	19379695
Cross	DVL2	O14641	Smurf2	Mus musculus	A2A5Z6	Lumier	19379695
Intra	DVL2	O14641	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	DVL2	O14641	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	DVL2	O14641	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	DVL2	O14641	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	DVL2	O14641	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	DVL2	O14641	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	DVL2	O14641	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	DVL2	O14641	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	DVL2	O14641	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	DVL2	O14641	TP53	Homo sapiens	P04637	Y2H Pooling	16189514
Intra	DVL2	O14641	TP53	Homo sapiens	P04637	Y2H Array	16713569
Intra	DVL2	O14641	TP53	Homo sapiens	P04637	Validated Y2H	27107012
Intra	DVL2	O14641	TP53	Homo sapiens	P04637	Y2H Array	31515488
Intra	DVL2	O14641	TP53	Homo sapiens	P04637	BFG-2H	27107012
Intra	DVL2	O14641	DACT1	Homo sapiens	Q9NYF0	Anti Tag CoIP	16446366
Intra	DVL2	O14641	DACT1	Homo sapiens	Q9NYF0	IF	21262972
Intra	DVL2	O14641	DACT1	Homo sapiens	Q9NYF0	Imaging	16446366
Intra	DVL2	O14641	RIPK4	Homo sapiens	P57078	Protein Kinase Assay	23371553
Intra	DVL2	O14641	RIPK4	Homo sapiens	P57078	Anti Bait CoIP	23371553
Intra	DVL2	O14641	RIPK4	Homo sapiens	P57078	Anti Tag CoIP	23371553
Intra	DVL2	O14641	LRRK2	Homo sapiens	Q5S007	Y2H	19625296
Intra	DVL2	O14641	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	19625296
Intra	DVL2	O14641	TRIM29	Homo sapiens	Q14134	IF	19249679
Intra	DVL2	O14641	TRIM29	Homo sapiens	Q14134	Anti Tag CoIP	19249679
Intra	DVL2	O14641	TRIM29	Homo sapiens	Q14134	Anti Bait CoIP	19249679
Intra	DVL2	O14641	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	22773187
Intra	DVL2	O14641	UIMC1	Homo sapiens	Q96RL1	Y2H	21516116
Intra	DVL2	O14641	UIMC1	Homo sapiens	Q96RL1	Y2H Array	29892012
Intra	DVL2	O14641	TIFA	Homo sapiens	Q96CG3	Y2H Pooling	16189514
Intra	DVL2	O14641	TIFA	Homo sapiens	Q96CG3	Validated Y2H	27107012
Intra	DVL2	O14641	DVL2	Homo sapiens	O14641	Validated Y2H	27107012
Intra	DVL2	O14641	DVL2	Homo sapiens	O14641	BFG-2H	27107012
Intra	DVL2	O14641	DVL2	Homo sapiens	O14641	Y2H Pooling	16189514
Intra	DVL2	O14641	DVL2	Homo sapiens	O14641	Pull Down	16189514
Intra	DVL2	O14641	ZNF165	Homo sapiens	P49910	Y2H Array	31515488
Intra	DVL2	O14641	ZNF165	Homo sapiens	P49910	Pull Down	16189514
Intra	DVL2	O14641	ZNF165	Homo sapiens	P49910	Y2H Pooling	16189514
Intra	DVL2	O14641	WWTR1	Homo sapiens	Q9GZV5	Anti Tag CoIP	20412773
Cross	DVL2	O14641	Pard6a	Mus musculus	Q9Z101	Anti Tag CoIP	19379695
Cross	DVL2	O14641	Pard6a	Mus musculus	Q9Z101	TAP	19379695
Intra	DVL2	O14641	CK1E	Homo sapiens	Q5R2U3	Lumier	20412773
Intra	DVL2	O14641	CK1E	Homo sapiens	Q5R2U3	Anti Tag CoIP	20412773

Cross: Cross-species interaction Intra: Intraspecies interaction

DVL2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82943	Phospho-Dishevelled 2 (Ser143) Antibody (YA2688)	WB	Human, Mouse
HY-P82943A	Phospho-Dishevelled 2 (Ser143) Antibody (YA2688)(PBS only)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of	Vlcad Deficiency Very Long Chain Acyl-Coa Dehydrogenase Deficiency Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency Lcad Deficiency Very Long-Chain Acyl-Coa Dehydrogenase Deficiency Long Chain Acyl-Coa Dehydrogenase Deficiency ACADVLD Acadl Deficiency Vlcadd Long-Chain Acyl-Coa Dehydrogenase Deficiency Acadvl Acyl-Coa Dehydrogenase Very Long Chain Deficiency Very Long-Chain Acyl Coenzyme A Dehydrogenase Deficiency Vlcad-C Vlcad-H Acyl-Coa Dehydrogenase, Very Long Chain, Deficiency Of Acyl-Coa Dehydrogenase Very Long-Chain Deficiency Acyl-Coa Dehydrogenase Long-Chain Deficiency Deficiency, Very Long Chain Acyl-Coa Dehydrogenase Long Chain/Very Long Chain Acyl Coa Dehydrogenase Deficiency
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15825	IWP L6	Inhibitor	98.71%	Unkown
HY-100853	IWP-O1	Inhibitor	99.81%	Unkown
HY-15825G	IWP L6 (GMP)	Inhibitor	/	Unkown
HY-RS04077	DVL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N0836A	Jervine hydriodide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DVL2	MGD	MGI:106613
Felis catus	DVL2	VGNC	VGNC:61672
Bos taurus	DVL2	VGNC	VGNC:28265
Macaca mulatta	DVL2	VGNC	VGNC:104598
Rattus norvegicus	DVL2	RGD	RGD:1309725
Canis familiaris	DVL2	VGNC	VGNC:40138
Others	DVL2	NCBI