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RIPK4 - receptor interacting serine/threonine kinase 4 Gene

Also Known as DIK; PKK; PPS2; RIP4; ANKK2; NKRD3; ANKRD3; CHANDS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54101

About RIPK4

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,739,373-41,767,052 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues, 1 paralogue and is associated with 5 phenotypes. Broad expression in esophagus (RPKM 16.7), kidney (RPKM 9.9) and 16 other tissues.

Summary

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]

RIPK4 Products (1)

mRNA	Protein	Name
NM_020639.3	NP_065690.2	receptor-interacting serine/threonine-protein kinase 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21931591	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in morphogenesis of an epithelium	IMP IMP: Inferred from mutant phenotype	22197488	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21931591	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIPK4 Protein Structure

Pkinase

Ank_2

Ank_4

Ank_2

0
200
400
600
832 a.a.

Protein Preferred Names	Protein Names
receptor-interacting serine/threonine-protein kinase 4	PKC-delta-interacting protein kinase

RIPK4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RIPK4	P57078	HIF1AN	Homo sapiens	Q9NWT6	Anti Tag CoIP	26972000

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bartsocas-Papas Syndrome 1	Bartsocas-Papas Syndrome Multiple Pterygium Syndrome, Aslan Type Popliteal Pterygium Syndrome, Lethal Type Popliteal Pterygium Syndrome, Bartsocas-Papas Type BPS Popliteal Pterygium Syndrome Lethal Type BPS1 Popliteal Pterygium Syndrome, Bartsocas-Papas Type 1 Pterygium, Popliteal, Lethal Type Bartsocas Papas Syndrome Pterygium Popliteal Lethal Type Autosomal Recessive Popliteal Pterygium Syndrome Lethal Popliteal Pterygium Syndrome
Chand Syndrome	CHANDS Curly Hair-Ankyloblepharon-Nail Dysplasia Syndrome Curly Hair, Ankyloblepharon, Nail Dysplasia Syndrome Baughman Syndrome
Popliteal Pterygium Syndrome	PPS Faciogenitopopliteal Syndrome Facio-Genito-Popliteal Syndrome Popliteal Web Syndrome Autosomal Dominant Popliteal Pterygium Syndrome Cleft Lip/Palate, Paramedian Mucous Cysts Of The Lower Lip, Popliteal Pterygium, Digital And Genital Anomalies Popliteal Pterygium Syndrome 1 Cleft Lip/Palate Paramedian Mucous Cysts Of The Lower Lip Popliteal Pterygium Digital And Genital Anomalies Popliteal Pterygium
Fetal Encasement Syndrome	Cocoon Syndrome COCOS Fetal Diseases
Synostosis
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate	Hay-Wells Syndrome Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome Aec Syndrome AEC Ankyloblepharon-Ectodermal Defects-Cleft Lip And Palate Syndrome Seres-Santamaria Arimany Muniz Syndrome Cleft Palate, Ankyloblepharon, Alveolar Synechiae, And Ectodermal Defects Ankyloblepharon Ectodermal Defects Cleft Lip/Palate Ankyloblepharon-Ectodermal Defect-Cleft Lip/Palate Rapp-Hodgkin Syndrome
Chronic Cervicitis
Van Der Woude Syndrome	Lip-Pit Syndrome Vws Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip Vdws Lps Lip Pit Syndrome Cleft Lip/Palate With Mucous Cysts Of Lower Lip Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments
Multiple Pterygium Syndrome, Escobar Variant	Multiple Pterygium Syndrome Pterygium Escobar Syndrome EVMPS Pterygium Syndrome Autosomal Recessive Multiple Pterygium Syndrome Pterygium Colli Syndrome Pterygium Universale Autosomal Recessive Non-Lethal Multiple Pterygium Syndrome Escobar Variant Multiple Pterygium Syndrome Multiple Pterygium Syndrome, Nonlethal Type Surfer'S Eye Multiple Pterygium Syndrome Escobar Type Multiple Pterygium Syndrome Nonlethal Type Familial Pterygium Syndrome Pterygium Colli Multiple Pterygium Syndrome, Non-Lethal Type Nonlethal Type Multiple Pterygium Syndrome Pterygium Syndrome, Multiple, Escobar Type Pterygium Of Eye Web Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148907	CS640	Inhibitor	99.48%	Unkown
HY-157456	RIPK1-IN-19	Inhibitor	98.87%	Unkown
HY-RS12001	RIPK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20482	Ripk4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26990	Ripk4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RIPK4	VGNC	VGNC:76882
Bos taurus	RIPK4	VGNC	VGNC:33983
Rattus norvegicus	RIPK4	RGD	RGD:1311691
Canis familiaris	RIPK4	VGNC	VGNC:45596
Felis catus	RIPK4	VGNC	VGNC:67586
Mus musculus	RIPK4	MGD	MGI:1919638
Others	RIPK4	NCBI