2. Neuronal Signaling MAPK/ERK Pathway Apoptosis
  3. CaMK MEK Mixed Lineage Kinase RIP kinase Tau Protein
  4. CS640

CS640 (Compound 19) is a chemical probe and a calmodulin-dependent kinase inhibitor. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, MEK5, RIPK4, mLK3 and PIP5K1, with IC50 values of 8, 3, 1, 1, 25 nM, 5.69, 2.75 and 11.2 μM, respectively. CS640 blocks Aβ-induced hyperphosphorylation of tau protein at the Thr181 site, but fails to protect primary mouse cortical neurons from Aβ-induced toxic damage. CS640 is applicable to research related to Alzheimer's disease.

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CS640

CS640 Chemical Structure

CAS No. : 2388506-83-8

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Customer Review

Based on 1 publication(s) in Google Scholar

CS640 Related Antibodies

Top Publications Citing Use of Products

View All CaMK Isoform Specific Products:

View All Isoforms
CaMK II CaMK III/eEF-2K CAMK IV PHK Trio DCAMKL

View All MEK Isoform Specific Products:

View All Isoforms
MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

View All RIP kinase Isoform Specific Products:

View All Isoforms
RIPK1 RIPK2 RIPK3

  • Biological Activity

  • Purity & Documentation

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Description

CS640 (Compound 19) is a chemical probe and a calmodulin-dependent kinase inhibitor. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, MEK5, RIPK4, mLK3 and PIP5K1, with IC50 values of 8, 3, 1, 1, 25 nM, 5.69, 2.75 and 11.2 μM, respectively. CS640 blocks Aβ-induced hyperphosphorylation of tau protein at the Thr181 site, but fails to protect primary mouse cortical neurons from Aβ-induced toxic damage. CS640 is applicable to research related to Alzheimer's disease[1][2].

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 IC50
0.011 μM
Compound: 19
Inhibition of HA-tagged CAMK1D (unknown origin) expressed in human MDA-MB-231 cells assessed as reduction in CAMK1D autophosphorylation measured after 4 hrs by Western blot analysis
Inhibition of HA-tagged CAMK1D (unknown origin) expressed in human MDA-MB-231 cells assessed as reduction in CAMK1D autophosphorylation measured after 4 hrs by Western blot analysis
[PMID: 32433887]
In Vitro

CS640 (1 nM-10 μM; 24 h) shows no significant neurotoxicity in mouse primary cortical neurons at concentrations up to 1 μM, but is highly toxic at 10 μM[2].
CS640 (10 nM-1 μM; 24 h) does not consistently rescue mouse primary cortical neurons from Aβ1-42-induced toxicity at concentrations up to 1 μM[2].
CS640 (1 μM; 12 h) reverses Aβ1-42-induced hyperphosphorylation of tau at Thr181 in mouse primary cortical neurons, reducing phosphorylated tau levels to near control levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CS640 Related Antibodies
Parmacokinetics
Species Dose Route Bioavailability AUC0-∞ Cmax T1/2 CL Vss
Mice[1] 2 mg/kg i.v. / 2454 ng·h/mL 503 ng/mL 8.3 h 13.7 mL/min/kg 7.46 L/kg
Mice[1] 10 mg/kg p.o. 44 % 5408 ng·h/mL 387 ng/mL 5.9 h / /
Mice[1] 20 mg/kg p.o. 118 % 28923 ng·h/mL 2015 ng/mL 5.9 h / /
Mice[1] 40 mg/kg p.o. 100 % 49220 ng·h/mL 3792 ng/mL 6.2 h / /
Rat[1] 2 mg/kg i.v. / 913 ng·h/mL 391 ng/mL 7.7 h 36.5 mL/min/kg 18.5 L/kg
Rat[1] 10 mg/kg p.o. 67.5 % 3058 ng·h/mL 199 ng/mL 7.0 h / /
Molecular Weight

397.52

Formula

C21H31N7O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC(C1=CN=C(N2C[C@H](CCC2)N)N=C1NC3=CC(C(C)C)=NC(C(C)C)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (12.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5156 mL 12.5780 mL 25.1560 mL
5 mM 0.5031 mL 2.5156 mL 5.0312 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5156 mL 12.5780 mL 25.1560 mL 62.8899 mL
5 mM 0.5031 mL 2.5156 mL 5.0312 mL 12.5780 mL
10 mM 0.2516 mL 1.2578 mL 2.5156 mL 6.2890 mL
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CS640 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CS6402388506-83-8CS 640CS-640CaMKMEKMixed Lineage KinaseRIP kinaseTau ProteinCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesMitogen-activated protein kinase kinaseMAPKKMAP2KMLKsReceptor-interacting protein kinasesRIPKATP binding pocketthreonine 180MEK5mouse modelsCaMKI isoformsserine 179tau hyperphosphorylationalzheimer’s diseasemouse primary cortical neuronsCaMK1DInhibitorinhibitorinhibit

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