HIF1AN - hypoxia inducible factor 1 subunit alpha inhibitor Gene

Also Known as FIH1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55662

About HIF1AN

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,535,943-100,559,998 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 12.2), skin (RPKM 8.6) and 25 other tissues.

Summary

Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; and protein hydroxylation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HIF1AN Products (1)

mRNA Protein Name
NM_017902.3 NP_060372.2 hypoxia-inducible factor 1-alpha inhibitor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
17003112 GOA
enables Notch binding IPI
IPI: Inferred from physical interaction
17573339 GOA
enables [protein]-asparagine 3-dioxygenase activity IDA
IDA: Inferred from direct assay
12080085 GOA
enables [protein]-asparagine 3-dioxygenase activity IMP
IMP: Inferred from mutant phenotype
19245366 GOA
enables ankyrin repeat binding IPI
IPI: Inferred from physical interaction
17003112 GOA
enables carboxylic acid binding IDA
IDA: Inferred from direct assay
17135241 GOA
enables ferrous iron binding IDA
IDA: Inferred from direct assay
12446723 GOA
enables peptidyl-aspartic acid 3-dioxygenase activity IDA
IDA: Inferred from direct assay
21177872 GOA
enables peptidyl-histidine dioxygenase activity IDA
IDA: Inferred from direct assay
21251231 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11641274 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12446723 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
11641274 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
12446723 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
18299578 GOA
involved in positive regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
18299578 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14734545 GOA
colocalizes with nucleus IDA
IDA: Inferred from direct assay
18299578 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19726677 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIF1AN Protein Structure

Cupin_8

Cupin_8: Cupin-like domain (53 - 298)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
Protein Preferred Names Protein Names

hypoxia-inducible factor 1-alpha inhibitor

  • FIH-1

HIF1AN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HIF1AN Q9NWT6 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
28514442
Intra
HIF1AN Q9NWT6 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
26752685
Intra
HIF1AN Q9NWT6 OTUB1 Homo sapiens Q96FW1
Hydroxylase Assay
26752685
Intra
HIF1AN Q9NWT6 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
33961781
Intra
HIF1AN Q9NWT6 TNKS Homo sapiens O95271
Enzymatic Study
21251231
Intra
HIF1AN Q9NWT6 TNKS Homo sapiens O95271
Anti Tag CoIP
28514442
Intra
HIF1AN Q9NWT6 TNKS Homo sapiens O95271
Hydroxylase Assay
17003112
Intra
HIF1AN Q9NWT6 TNKS Homo sapiens O95271
Anti Tag CoIP
33961781
Intra
HIF1AN Q9NWT6 TNKS Homo sapiens O95271
Anti Tag CoIP
26972000
Intra
HIF1AN Q9NWT6 ANKRD50 Homo sapiens Q9ULJ7-2
Validated Y2H
32296183
Intra
HIF1AN Q9NWT6 NFKB1 Homo sapiens P19838
Y2H
17003112
Intra
HIF1AN Q9NWT6 NFKB1 Homo sapiens P19838
Hydroxylase Assay
17003112
Intra
HIF1AN Q9NWT6 NFKB1 Homo sapiens P19838
Decarboxylation
17003112
Intra
HIF1AN Q9NWT6 NFKB1 Homo sapiens P19838
Anti Tag CoIP
17003112
Intra
HIF1AN Q9NWT6 NFKBIA Homo sapiens P25963
Anti Bait CoIP
17003112
Intra
HIF1AN Q9NWT6 NFKBIA Homo sapiens P25963
Anti Tag CoIP
26972000
Intra
HIF1AN Q9NWT6 NFKBIA Homo sapiens P25963
Hydroxylase Assay
17003112
Intra
HIF1AN Q9NWT6 FEM1B Homo sapiens Q9UK73
Anti Tag CoIP
17003112
Intra
HIF1AN Q9NWT6 FEM1B Homo sapiens Q9UK73
Y2H
17003112
Intra
HIF1AN Q9NWT6 FEM1B Homo sapiens Q9UK73
Hydroxylase Assay
17003112
Intra
HIF1AN Q9NWT6 UACA Homo sapiens Q9BZF9
Y2H
17003112
Intra
HIF1AN Q9NWT6 UACA Homo sapiens Q9BZF9
Anti Tag CoIP
17003112
Intra
HIF1AN Q9NWT6 TNKS2 Homo sapiens Q9H2K2
Anti Tag CoIP
33961781
Intra
HIF1AN Q9NWT6 TNKS2 Homo sapiens Q9H2K2
Anti Tag CoIP
26972000
Intra
HIF1AN Q9NWT6 TNKS2 Homo sapiens Q9H2K2
Anti Tag CoIP
28514442
Intra
HIF1AN Q9NWT6 TNKS2 Homo sapiens Q9H2K2
Enzymatic Study
21251231
Intra
HIF1AN Q9NWT6 RIPK4 Homo sapiens P57078
Anti Tag CoIP
26972000
Intra
HIF1AN Q9NWT6 HIF1A Homo sapiens Q16665
Hydroxylase Assay
17003112
Intra
HIF1AN Q9NWT6 HIF1A Homo sapiens Q16665
Decarboxylation
17003112
Intra
HIF1AN Q9NWT6 HIF1A Homo sapiens Q16665
Hydroxylase Assay
26752685
Intra
HIF1AN Q9NWT6 HIF1A Homo sapiens Q16665
Anti Tag CoIP
26972000
Intra
HIF1AN Q9NWT6 HIF1A Homo sapiens Q16665
X-Ray Diffraction
12446723
Intra
HIF1AN Q9NWT6 HIF1A Homo sapiens Q16665
Anti Tag CoIP
26751287
Intra
HIF1AN Q9NWT6 APBA3 Homo sapiens O96018
Anti Tag CoIP
29426014
Intra
HIF1AN Q9NWT6 APBA3 Homo sapiens O96018
Anti Tag CoIP
33961781
Intra
HIF1AN Q9NWT6 APBA3 Homo sapiens O96018
Anti Tag CoIP
26948053
Intra
HIF1AN Q9NWT6 APBA3 Homo sapiens O96018
Anti Tag CoIP
28514442
Intra
HIF1AN Q9NWT6 APBA3 Homo sapiens O96018
Anti Bait CoIP
26948053
Intra
HIF1AN Q9NWT6 ASB13 Homo sapiens Q8WXK3
Anti Tag CoIP
26972000
Intra
HIF1AN Q9NWT6 ASB13 Homo sapiens Q8WXK3
Y2H Pooling
16189514
Intra
HIF1AN Q9NWT6 ASB9 Homo sapiens Q96DX5
Y2H Pooling
16189514
Intra
HIF1AN Q9NWT6 ILK Homo sapiens Q13418
Anti Tag CoIP
26972000
Intra
HIF1AN Q9NWT6 ILK Homo sapiens Q13418
Hydroxylase Assay
17003112
Intra
HIF1AN Q9NWT6 PSMD10 Homo sapiens O75832
Hydroxylase Assay
17003112
Intra
HIF1AN Q9NWT6 PSMD10 Homo sapiens O75832
Anti Tag CoIP
26972000
Intra
HIF1AN Q9NWT6 ANKRD49 Homo sapiens Q8WVL7
Hydroxylase Assay
17003112
Intra
HIF1AN Q9NWT6 ANKRD49 Homo sapiens Q8WVL7
Anti Tag CoIP
29426014
Intra
HIF1AN Q9NWT6 ANKRD49 Homo sapiens Q8WVL7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

HIF1AN Antibodies

Cat. No. Product Name Application Reactivity
HY-P82162 HIF1AN Antibody (YA1907) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Erythrocytosis, Familial, 4

  • ECYT4

  • Familial Erythrocytosis 4

  • Erythrocytosis, Familial, Type 4
Erythrocytosis, Familial, 5

  • ECYT5

  • Familial Erythrocytosis 5
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Erythrocytosis, Familial, 2

  • Chuvash Polycythemia

  • ECYT2

  • Familial Erythrocytosis 2

  • Autosomal Recessive Benign Erythrocytosis

  • Polycythemia, Vhl-Dependent

  • Chuvash Erythromatosis

  • Chuvash Type Polycythemia

  • Chuvash Erythrocytosis

  • Von Hippel-Lindau-Dependent Polycythemia

  • Polycythemia Chuvash Type

  • Vhl-Dependent Polycythemia

  • Erythrocytosis, Familial, Type 2
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06169 HIF1AN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HIF1AN RGD RGD:1308281
Felis catus HIF1AN VGNC VGNC:97455
Canis familiaris HIF1AN VGNC VGNC:41687
Mus musculus HIF1AN MGD MGI:2442345
Bos taurus HIF1AN VGNC VGNC:29849
Macaca mulatta HIF1AN VGNC VGNC:81417
Others HIF1AN NCBI