ILK - integrin linked kinase Gene

Also Known as P59; ILK-1; ILK-2; p59ILK; HEL-S-28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3611

About ILK

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,603,774-6,610,870 (from NCBI)

This gene has 16 transcripts (splice variants), 254 orthologues and 23 paralogues. Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues.

Summary

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

ILK Products (5)

mRNA	Protein	Name
NM_001014794.3	NP_001014794.1	integrin-linked protein kinase isoform 1
NM_001014795.3	NP_001014795.1	integrin-linked protein kinase isoform 1
NM_001278441.2	NP_001265370.1	integrin-linked protein kinase isoform 2
NM_001278442.2	NP_001265371.1	integrin-linked protein kinase isoform 3
NM_004517.4	NP_004508.1	integrin-linked protein kinase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	20005845	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	20005845	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	20005845	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11331308	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19118217	GOA
NOT enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	20005845	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	30254023	GOA
acts upstream of or within integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	9366252	GOA
involved in mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	18283114	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20018240	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21343177	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20018240	GOA
involved in positive regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	10637513	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IGI IGI: Inferred from genetic interaction	30254023	GOA
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19118217	GOA
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21343177	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	18283114	GOA
located in chromatin	IDA IDA: Inferred from direct assay	17420447	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17420447	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	30254023	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17420447	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ILK Protein Structure

Ank

Ank_2

Pkinase_Tyr

0
100
200
300
400
452 a.a.

Protein Preferred Names	Protein Names
integrin-linked protein kinase	59 kDa serine/threonine-protein kinase

ILK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059-3	Y2H Prey Pooling	32296183
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059-3	Y2H Array	32296183
Intra	ILK	Q13418	RICTOR	Homo sapiens	Q6R327	Y2H	18339839
Intra	ILK	Q13418	RICTOR	Homo sapiens	Q6R327	Anti Bait CoIP	18339839
Intra	ILK	Q13418	RICTOR	Homo sapiens	Q6R327	Anti Tag CoIP	18339839
Intra	ILK	Q13418	SLC4A1AP	Homo sapiens	Q9BWU0	Anti Tag CoIP	17553790
Intra	ILK	Q13418	SLC4A1AP	Homo sapiens	Q9BWU0	Pull Down	17553790
Intra	ILK	Q13418	ILKAP	Homo sapiens	Q9H0C8	Anti Bait CoIP	11331582
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	Pull Down	19074270
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	Anti Tag CoIP	35271311
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	BiFC	23877428
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	Y2H	11331308
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	Pull Down	32707033
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	Anti Bait CoIP	17353931
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	X-Ray Diffraction	19074270
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	Anti Tag CoIP	18339839
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	TAP	23455922
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	GMS	19074270
Intra	ILK	Q13418	LIMS1	Homo sapiens	P48059	Anti Tag CoIP	25852190
Intra	ILK	Q13418	SYNPO2	Homo sapiens	Q9UMS6	Anti Bait CoIP	21643011
Intra	ILK	Q13418	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	ILK	Q13418	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	ILK	Q13418	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	ILK	Q13418	PARVG	Homo sapiens	Q9HBI0	Y2H Prey Pooling	25416956
Intra	ILK	Q13418	PARVG	Homo sapiens	Q9HBI0	Validated Y2H	32296183
Intra	ILK	Q13418	PARVG	Homo sapiens	Q9HBI0	Y2H Array	25416956
Intra	ILK	Q13418	CASP9	Homo sapiens	P55211	Anti Bait CoIP	16936772
Intra	ILK	Q13418	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Validated Y2H	25416956
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Y2H Prey Pooling	32296183
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	TAP	23455922
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Anti Tag CoIP	26496610
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Validated Y2H	32296183
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Y2H Array	25416956
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Anti Tag CoIP	25852190
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Anti Tag CoIP	33961781
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Y2H	11331308
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Y2H Array	32296183
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Y2H Pooling	16189514
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	BiFC	23877428
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Pull Down	17553790
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Pull Down	32707033
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Y2H Prey Pooling	25416956
Intra	ILK	Q13418	PARVA	Homo sapiens	Q9NVD7	Anti Tag CoIP	35271311
Intra	ILK	Q13418	CASP8	Homo sapiens	Q14790	Anti Bait CoIP	16936772

Cross: Cross-species interaction Intra: Intraspecies interaction

ILK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83366	Integrin Linked ILK Antibody (YA3111)	WB, IP	Human, Mouse, Rat
HY-P83366A	Integrin Linked ILK Antibody (YA3111)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Renal Fibrosis
Hyperphosphatemia
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113439	12-HETE	Inhibitor	95.70%	Unkown
HY-18676	OSU-T315		99.88%	Unkown
HY-115677	ILK-IN-3	Inhibitor	99.62%	Unkown
HY-18676B	ILK-IN-2		99.41%	Unkown
HY-113439S	12-HETE-d8	Inhibitor	98.03%	Unkown
HY-P4866	Q-Peptide		99.46%	Unkown
HY-177912	ILK-IN-4	Inhibitor	/	Unkown
HY-184113	Dihydropelitinib		/	Unkown
HY-RS06787	ILK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16756	Ilk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23195	Ilk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ILK	VGNC	VGNC:73738
Mus musculus	ILK	MGD	MGI:1195267
Rattus norvegicus	ILK	RGD	RGD:620063
Bos taurus	ILK	VGNC	VGNC:30177
Canis familiaris	ILK	VGNC	VGNC:42001
Felis catus	ILK	VGNC	VGNC:67792
Others	ILK	NCBI