Cat. No.: HY-P4866

Q-Peptide

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Based on 1 Customer Validation

Q-Peptide is an angiopoietin-1 derived peptide (QHREDGS). Q-Peptide interacts with β1-integrin, binds to integrins on the surface of osteoblasts, and serves as an acyl donor substrate for Streptomyces mobaraensis transglutaminase. Q-Peptide activates Akt, MAPKp42/44, ILK, ERK1/2, and downregulates caspase-3/7. Q-Peptide inhibits cell apoptosis, enhances cell adhesion and migration, and promotes osteoblast differentiation, bone matrix deposition and mineralization. Q-Peptide can be used in studies related to myocardial infarction, bone regeneration, diabetic wound repair and human induced pluripotent stem cells.

For research use only. We do not sell to patients.

Purity: 99.46%
CAS No.: 1361235-89-3
Formula: C₃₁H₄₉N₁₃O₁₄
Molecular Weight:827.80

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Q-Peptide Chemical Structure

CAS No.: 1361235-89-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[3]

Akt

p38 MAPK

ERK1

ERK2

Caspase 3

Caspase-7

All Integrin Isoforms :

All Transglutaminase Isoforms :

TGM2

All Akt Isoforms :

All p38 MAPK Isoforms :

All ERK Isoforms :

All Caspase Isoforms :

In Vitro

Q-Peptide (QHREDGS) (5-500 μM; 5 continuous passages, 7 days) improves human induced pluripotent stem cell (BJ1D, 0901B, IMR90) expansion and viability in feeder-dependent culture by reducing caspase-dependent apoptosis, without altering proliferation, while having no significant effect on human embryonic stem cells (H9)^[1].
Q-Peptide (50 μM; 5 continuous passages) preserves the in vitro pluripotency of human induced pluripotent stem cells (BJ1D, 0901B)^[1].
Q-Peptide (5-500 μM; 48h) significantly increases colony number and size in feeder-free human induced pluripotent stem cells cultured on Matrigel^[1].
Q-Peptide (50 μM; 0min-24h) increases integrin-linked kinase (ILK) expression, and increases expression and activation of extracellular signal-regulated kinases 1/2 (ERK1/2) across multiple time points, without affecting AKT activation^[1].
Q-Peptide (7.2-29.0 mM; 6h) dose-dependently enhances human induced pluripotent stem cell adhesion to non-adhesive PEG hydrogels, and this interaction is mediated by β1-integrins^[1].
Q-Peptide (200 μM; 40 min) potently acts as a substrate for Streptomyces mobaraensis transglutaminase (STG), with a cross-linking conversion yield of 93.0%^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

human induced pluripotent stem cells
Concentration:

50 μM
Incubation Time:

0min, 30min, 1.5h, 2h, 4h, 24h
Result:

Increased ILK protein expression.
Significantly upregulated ERK1/2 expression.
Showed no increase in AKT phosphorylation.

In Vivo

Q-Peptide (2.2 nmol; topical; single application) significantly accelerates diabetic wound healing in db/db mice by promoting re-epithelialization and granulation tissue formation; it is significantly superior to clinically approved collagen dressings in accelerating diabetic wound healing in db/db mice, achieving near-complete wound closure by day 21^[3].
QP-derived functional peptide hydrogel (1% w/v, for local single injection) mediated mesenchymal stem cell transplantation can improve cardiac function (EF and FS), reduce infarct size, collagen content and cardiomyocyte apoptosis in rat myocardial infarction models. This treatment also elevates the survival rate of transplanted cells and promotes angiogenesis. Ctf1 pretreatment can further enhance the therapeutic effects of QP-based hydrogel mediated mesenchymal stem cell transplantation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BKS.Cg-Dock7m+/+Leprdb/J (db/db) (8-week-old male, leptin-receptor deficient type 2 diabetic, full-thickness 8-mm dorsal excisional wounds)^[3]
Dosage:

2.2 nmol
5.9 nmol
Administration:

topical; single application
Result:

Showed faster wound closure starting on day 8.
Reduced normalized wound area significantly by day 14 compared to blank or peptide-free hydrogel controls.
Reduced epithelial gap significantly compared to controls.
Increased re-epithelialization percentage significantly compared to controls.
Enlarged granulation tissue area significantly compared to controls.
Thinned advancing epidermal tongue significantly compared to controls.
Increased total number of blood vessels in the wound significantly compared to blank and peptide-free hydrogel controls.
Was significantly superior to clinically approved collagen dressings in accelerating diabetic wound healing in db/db mice, achieving near-complete wound closure by day 21

Chemical Information

CAS No. 1361235-89-3
Appearance Solid
Molecular Weight 827.80
Formula C₃₁H₄₉N₁₃O₁₄
Color White to off-white
Sequence

Gln-His-Arg-Glu-Asp-Gly-Ser
Sequence Shortening

QHREDGS
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (120.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2080 mL

6.0401 mL

12.0802 mL

5 mM

0.2416 mL

1.2080 mL

2.4160 mL

10 mM

0.1208 mL

0.6040 mL

1.2080 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dang LT, et al. Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS. Biomaterials. 2014;35(27):7786-7799. [Content Brief]

[2]. Feric N, et al. Angiopoietin-1 peptide QHREDGS promotes osteoblast differentiation, bone matrix deposition and mineralization on biomedical materials. Biomater Sci. 2014;2(10):1384-1398. [Content Brief]

[3]. Xiao Y, et al. Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization. Proc Natl Acad Sci U S A. 2016;113(40):E5792-E5801. [Content Brief]

[4]. Lee JH, et al. Glutamine (Q)-peptide screening for transglutaminase reaction using mRNA display. Biotechnol Bioeng. 2013;110(2):353-362. [Content Brief]

[5]. Cai H, et al. Self-assembling peptide modified with QHREDGS as a novel delivery system for mesenchymal stem cell transplantation after myocardial infarction. FASEB J. 2019;33(7):8306-8320. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.2080 mL	6.0401 mL	12.0802 mL	30.2005 mL
	5 mM	0.2416 mL	1.2080 mL	2.4160 mL	6.0401 mL
	10 mM	0.1208 mL	0.6040 mL	1.2080 mL	3.0201 mL
	15 mM	0.0805 mL	0.4027 mL	0.8053 mL	2.0134 mL
	20 mM	0.0604 mL	0.3020 mL	0.6040 mL	1.5100 mL
	25 mM	0.0483 mL	0.2416 mL	0.4832 mL	1.2080 mL
	30 mM	0.0403 mL	0.2013 mL	0.4027 mL	1.0067 mL
	40 mM	0.0302 mL	0.1510 mL	0.3020 mL	0.7550 mL
	50 mM	0.0242 mL	0.1208 mL	0.2416 mL	0.6040 mL
	60 mM	0.0201 mL	0.1007 mL	0.2013 mL	0.5033 mL
	80 mM	0.0151 mL	0.0755 mL	0.1510 mL	0.3775 mL
	100 mM	0.0121 mL	0.0604 mL	0.1208 mL	0.3020 mL

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Q-Peptide

Apoptosis Compound Library

Immunology/Inflammation Compound Library

MAPK Compound Library

Metabolism/Protease Compound Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Anti-diabetic Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Glycolysis Compound Library

Pyroptosis Compound Library

Cytoskeleton Compound Library

Glutamine Metabolism Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Peptide Library

Antidepressant Compound Library

Anti-Pulmonary Fibrosis Compound Library

Osteogenesis Compound Library

Pain-Related Compound Library

Mitochondrial Protection Compound Library

Protease Inhibitor Library

Membrane Protein-targeted Compound Library

Cell Death Library

Extracellular Vesicles (EVs) Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Peptide Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All Integrin Isoforms

All Transglutaminase Isoforms

All Akt Isoforms

All p38 MAPK Isoforms

All ERK Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Q-Peptide Related Classifications

Cat. No.: HY-P4866