1361235-89-3
Chemical Structure
Q-Peptide
- CAS No.: 1361235-89-3
- Formula:C31H49N13O14
- Molecular Weight:827.80
InChIKey: JBNPKUJQJBPSGV-RABCQHRBSA-N
SMILES: OC([C@H](CO)NC(CNC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](N)CCC(N)=O)=O)CC1=CN=CN1)=O)=O)=O)=O)=O)=O
Biological Activity: Q-Peptide is an angiopoietin-1 derived peptide (QHREDGS). Q-Peptide interacts with β1-integrin, binds to integrins on the surface of osteoblasts, and serves as an acyl donor substrate for Streptomyces mobaraensis transglutaminase. Q-Peptide activates Akt, MAPKp42/44, ILK, ERK1/2, and downregulates caspase-3/7. Q-Peptide inhibits cell apoptosis, enhances cell adhesion and migration, and promotes osteoblast differentiation, bone matrix deposition and mineralization. Q-Peptide can be used in studies related to myocardial infarction, bone regeneration, diabetic wound repair and human induced pluripotent stem cells[1][2][3][4][5].
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Q-Peptide | Q-Peptide is an angiopoietin-1 derived peptide (QHREDGS). Q-Peptide interacts with β1-integrin, binds to integrins on the surface of osteoblasts, and serves as an acyl donor substrate for Streptomyces mobaraensis transglutaminase. Q-Peptide activates Akt, MAPKp42/44, ILK, ERK1/2, and downregulates caspase-3/7. Q-Peptide inhibits cell apoptosis, enhances cell adhesion and migration, and promotes osteoblast differentiation, bone matrix deposition and mineralization. Q-Peptide can be used in studies related to myocardial infarction, bone regeneration, diabetic wound repair and human induced pluripotent stem cells. | |||||||||||||||||||||
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References
- [1]. Dang LT, et al. Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS. Biomaterials. 2014;35(27):7786-7799. [Content Brief]
- [2]. Feric N, et al. Angiopoietin-1 peptide QHREDGS promotes osteoblast differentiation, bone matrix deposition and mineralization on biomedical materials. Biomater Sci. 2014;2(10):1384-1398. [Content Brief]
- [3]. Xiao Y, et al. Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization. Proc Natl Acad Sci U S A. 2016;113(40):E5792-E5801. [Content Brief]
- [4]. Lee JH, et al. Glutamine (Q)-peptide screening for transglutaminase reaction using mRNA display. Biotechnol Bioeng. 2013;110(2):353-362. [Content Brief]
- [5]. Cai H, et al. Self-assembling peptide modified with QHREDGS as a novel delivery system for mesenchymal stem cell transplantation after myocardial infarction. FASEB J. 2019;33(7):8306-8320. [Content Brief]
