RICTOR - RPTOR independent companion of MTOR complex 2 Gene

Also Known as PIA; AVO3; hAVO3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 253260

About RICTOR

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:38,937,920-39,074,399 (from NCBI)

This gene has 10 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in bone marrow (RPKM 9.8), testis (RPKM 7.0) and 25 other tissues.

Summary

RICTOR and mTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

RICTOR Products (3)

mRNA	Protein	Name
NM_001285439.2	NP_001272368.1	rapamycin-insensitive companion of mTOR isoform 2
NM_001285440.2	NP_001272369.1	rapamycin-insensitive companion of mTOR isoform 3
NM_152756.5	NP_689969.2	rapamycin-insensitive companion of mTOR isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	29567957	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15467718	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21177249	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	16221682	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in TORC2 signaling	IDA IDA: Inferred from direct assay	16221682	GOA
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15268862	GOA
involved in peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	21177249	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	15467718	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15467718	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15718470	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of TORC2 complex	IDA IDA: Inferred from direct assay	15268862	GOA
part of TORC2 complex	IPI IPI: Inferred from physical interaction	17461779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RICTOR Protein Structure

RICTOR_N

RICTOR_M

RasGEF_N_2

RICTOR_V

RICTOR_phospho

0
300
600
900
1200
1500
1708 a.a.

Protein Preferred Names	Protein Names
rapamycin-insensitive companion of mTOR	AVO3 homolog

RICTOR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RICTOR	Q6R327	PREX1	Homo sapiens	Q8TCU6	Anti Tag CoIP	17565979
Intra	RICTOR	Q6R327	PREX1	Homo sapiens	Q8TCU6	Anti Tag CoIP	21339740
Intra	RICTOR	Q6R327	YWHAE	Homo sapiens	P62258	CoIP	19935711
Intra	RICTOR	Q6R327	YWHAE	Homo sapiens	P62258	TAP	17461779
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	TAP	17461779
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	Anti Bait CoIP	18339839
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	Anti Bait CoIP	17461779
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	Anti Bait CoIP	18566587
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	Anti Tag CoIP	17565979
Intra	RICTOR	Q6R327	SFN	Homo sapiens	P31947	TAP	15778465
Intra	RICTOR	Q6R327	ILK	Homo sapiens	Q13418	IF	18339839
Intra	RICTOR	Q6R327	ILK	Homo sapiens	Q13418	Anti Bait CoIP	18339839

Cross: Cross-species interaction Intra: Intraspecies interaction

RICTOR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80312	RICTOR Antibody (YA092)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P810541	Phospho-RICTOR (Thr1135) Antibody (YA9810)	WB	Human, Mouse
HY-P84642	RICTOR Antibody (YA4339)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P84642A	RICTOR Antibody (YA4339)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P86211	RICTOR Antibody (YA5903)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Subependymal Glioma	Mixed Subependymoma-Ependymoma Subependymal Astrocytoma Who Grade I Ependymal Tumor Glioma, Subependymal
Kidney Angiomyolipoma	Angiomyolipoma Of Kidney Renal Angiomyolipoma
Subependymal Giant Cell Astrocytoma	Sega Astrocytoma Subependymal Giant Cell Subependymal Giant-Cell Astrocytoma
Dravet Syndrome	Severe Myoclonic Epilepsy Of Infancy Severe Myoclonic Epilepsy In Infancy Smei Epileptic Encephalopathy, Early Infantile, 6 DRVT Developmental And Epileptic Encephalopathy 6a Dee6a Eiee6 Developmental And Epileptic Encephalopathy, 6 Dee6 Developmental And Epileptic Encephalopathy 6 Early Infantile Epileptic Encephalopathy 6 Myoclonic Epilepsy, Severe, Of Infancy Sme Severe Myoclonus Epilepsy Of Infancy Borderline Smei Smeb Smeb-M Smeb-O Smeb-Sw Smei-Borderland Smei-Borderland More Than One Feature Smei-Borderland-Myoclonic Seizures Smei-Borderland-Spike Wave Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures ICEGTC Infantile Severe Myoclonic Epilepsy Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Benign Ependymoma	Ependymoma Epithelial Ependymoma Who Grade Ii Ependymal Tumor Myxopapillary Ependymoma
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Myopathy	Muscular Diseases Myopathies
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19307	SB-273005		99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122022	JR-AB2-011	Inhibitor	98.15%	Unkown
HY-RS11969	RICTOR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17350	Rictor Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23804	Rictor Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RICTOR	VGNC	VGNC:64626
Canis familiaris	RICTOR	VGNC	VGNC:45574
Mus musculus	RICTOR	MGD	MGI:1926007
Bos taurus	RICTOR	VGNC	VGNC:33963
Rattus norvegicus	RICTOR	RGD	RGD:1307224
Macaca mulatta	RICTOR	VGNC	VGNC:76853
Others	RICTOR	NCBI