SYNPO2 - synaptopodin 2 Gene

Also Known as SYISL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 171024

About SYNPO2

This gene has 7 transcripts (splice variants), 273 orthologues and 2 paralogues. Broad expression in esophagus (RPKM 79.5), prostate (RPKM 71.0) and 14 other tissues.

Summary

Enables alpha-actinin binding activity and filamin binding activity. Involved in positive regulation of actin filament bundle assembly; positive regulation of cell migration; and regulation of Rho-dependent protein serine/threonine kinase activity. Located in several cellular components, including Z disc; focal adhesion; and stress fiber. [provided by Alliance of Genome Resources, Apr 2022]

SYNPO2 Products (7)

mRNA Protein Name
NM_001128933.3 NP_001122405.1 synaptopodin-2 isoform b
NM_001128934.3 NP_001122406.1 synaptopodin-2 isoform c
NM_001286754.2 NP_001273683.1 synaptopodin-2 isoform d
NM_001286755.2 NP_001273684.1 synaptopodin-2 isoform e
NM_001389263.1 NP_001376192.1 synaptopodin-2 isoform f
NM_001389264.1 NP_001376193.1 synaptopodin-2 isoform g
NM_133477.3 NP_597734.2 synaptopodin-2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-actinin binding IDA
IDA: Inferred from direct assay
20554076 GOA
enables filamin binding IDA
IDA: Inferred from direct assay
20554076 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21643011 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of actin filament bundle assembly IDA
IDA: Inferred from direct assay
24005909 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
22915763 GOA
involved in regulation of Rho-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
22915763 GOA
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
20554076 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
20554076 GOA
located in stress fiber IDA
IDA: Inferred from direct assay
20554076 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNPO2 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (11 - 84)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1093 a.a.
Protein Preferred Names Protein Names

synaptopodin-2

  • SYNPO2 intron sense-overlapping lncRNA

SYNPO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SYNPO2 Q9UMS6 ILK Homo sapiens Q13418
Pull Down
21643011
Intra
SYNPO2 Q9UMS6 ILK Homo sapiens Q13418
Confocal
21643011
Intra
SYNPO2 Q9UMS6 ILK Homo sapiens Q13418
Anti Bait CoIP
21643011
Intra
SYNPO2 Q9UMS6 ILK Homo sapiens Q13418
Y2H
21643011
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrotic Syndrome, Type 23

  • NPHS23

  • Nephrotic Syndrome Type 23

  • Nephrotic Syndrome 23
Nephrotic Syndrome, Type 21

  • NPHS21

  • Nephrotic Syndrome Type 21

  • Nephrotic Syndrome 21
Nephrotic Syndrome, Type 22

  • NPHS22

  • Nephrotic Syndrome Type 22

  • Nephrotic Syndrome 22
Muscular Dystrophy

  • Muscular Dystrophies

  • Congenital Md

  • Congenital Muscular Dystrophy

  • Cmd

  • Mdc

  • Dystrophy, Muscular

  • Gower'S Muscular Dystrophy

  • Progressive Musclular Dystrophy

  • Pseudohypertrophic Atrophy

  • Pseudohypertrophic Muscle Paralysis

  • Pseudohypertrophic Muscular Atrophy

  • Pseudohypertrophic Muscular Dystrophy

  • Pseudohypertrophic Paralysis

  • Pseudomuscular Hypertrophy
Myopathy, Myofibrillar, 2

  • Alpha-B Crystallinopathy

  • Myofibrillar Myopathy 2

  • MFM2

  • Myopathy, Myofibrillar, Alpha-B Crystallin-Related

  • Myopathy, Desmin-Related, Associated With Mutation In The Cryab Gene

  • Myopathy, Myofibrillar, With Or Without Cataract And/Or Cardiomyopathy

  • Alpha-B Crystallin-Related Late-Onset Myopathy

  • Alpha-B Crystallin-Related Late-Onset Distal Myopathy

  • Late-Onset Distal Crystallinopathy

  • Alpha-B Crystallinopathy With Cataract

  • Desmin-Related Myopathy With Cataract

  • Mfm Alpha-B Crystallin-Related

  • Myofibrillar Myopathy Alpha-B Crystallin-Related

  • Myofibrillar Myopathy With Or Without Cataract And/Or Cardiomyopathy

  • Myopathy Cardioskeletal Desmin-Related With Cataract

  • Myopathy Desmin-Related Associated With Mutation In The Cryab Gene

  • Myopathy, Cardioskeletal, Desmin-Related, With Cataract

  • Myopathy, Myofibrillar, Type 2
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Myofibrillar Myopathy

  • Desmin Related Myopathy

  • Myotilinopathy

  • Myopathy, Myofibrillar

  • Alpha Beta Crystallinopathy

  • Desmin Storage Myopathy

  • Desminopathy

  • Filaminopathy

  • Protein Surplus Myopathy

  • Zaspopathy

  • Myofibrillar Myopathies

  • Myopathy, Myofibrillar, Desmin-Related

  • Myopathy, Desmin Storage

  • Mfm - [Myofibrillar Myopathy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14098 SYNPO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14099 SYNPO2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SYNPO2 VGNC VGNC:78152
Rattus norvegicus SYNPO2 RGD RGD:1564779
Felis catus SYNPO2 VGNC VGNC:65889
Bos taurus SYNPO2 VGNC VGNC:35531
Canis familiaris SYNPO2 VGNC VGNC:47035
Mus musculus SYNPO2 MGD MGI:2153070
Others SYNPO2 NCBI