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OSU-T315 

Cat. No.: HY-18676 Purity: 99.42%
Handling Instructions

OSU-T315 is a novel ILK inhibitor with IC50 of 0.6 μM.

For research use only. We do not sell to patients.
OSU-T315 Chemical Structure

OSU-T315 Chemical Structure

CAS No. : 1333146-24-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 493 In-stock
2 mg USD 240 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

OSU-T315 is a novel ILK inhibitor with IC50 of 0.6 μM. IC50 value: 0.6 μM Target: ILK in vitro: OSU-T315 exhibits high potency against a panel of prostate and breast cancer cell lines (IC50, 1-2.5 μM). OSU-T315 facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including glycogen synthase kinase-3β and myosin light chain. OSU-T315 suppresses the expression of the transcription/translation factor YB-1 and its targets HER2 and EGFR in PC-3 cells, which could be rescued by the stable expression of constitutively active ILK. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. in vivo: OSU-T315 is a single oral agent in suppressing PC-3 xenograft tumor growth.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8741 mL 9.3705 mL 18.7410 mL
5 mM 0.3748 mL 1.8741 mL 3.7482 mL
10 mM 0.1874 mL 0.9370 mL 1.8741 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

533.59

Formula

C₃₀H₃₀F₃N₅O

CAS No.

1333146-24-9

SMILES

O=C(NC)CCC1=NN(C2=CC=C(N3CCNCC3)C=C2)C(C4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.42%

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Product Name:
OSU-T315
Cat. No.:
HY-18676
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