1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory Immune Checkpoint Molecules
  4. LIGHT

LIGHT (TNFSF14/CD258), a type II transmembrane glycoprotein, is a homologous to lymphotoxins, with inducible nature and the ability to compete with herpes simplex virus glycoprotein D for herpes virus entry mediator (HVEM). LIGHT is a tumor necrosis factor (TNF) superfamily ligand which regulates T cell immune responses by signaling through two primary functional receptors, the HVEM and the lymphotoxin beta receptor (LT-beta-R). LIGHT is expressed on activated T cells, NK cells, monocytes, granulocytes, and immature dendritic cells (DCs); HVEM is expressed on resting T cells, NK cells, monocytes, immature DCs, and endothelial cells; LT-beta-R is expressed on DCs, endothelial cells, and stromal cells but is not expressed on lymphocytes. LIGHT is also trapped by non-functional soluble decoy receptor 3 (DcR3), which is highly expressed in various human tumors, such as multiple myeloma and diffuse large B-cell lymphoma. As a co-stimulator of T cells, on engagement with LT-beta-R, LIGHT induces cytotoxicity against some human cancer cells, and promotes cytokine production and the release of the naive T cell-attracting chemokines in stromal cells, thus leading to the increased presence of lymphocytes in tissues. In addition, triggering of HVEM signals on T cells by LIGHT co-stimulates T cell proliferation and interferon IFN-gamma secretion in response to T cell receptor engagement, leading to enhanced T cell immunity. LIGHT has been in pre-clinical development for over a decade and shows promise as a modality of enhancing treatment approaches in the field of cancer immunotherapy.

Cat. No. Product Name / Synonyms Species Source
  • HY-P73837A
    LIGHT/TNFSF14 Protein, Mouse (sf9, His, solution)

    Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT  

    Mouse Sf9 insect cells
    LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Mouse LIGHT/TNFSF14 Protein has 239 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Mouse (sf9, His, solution) is the extracellular part (D72-V239) of mouse LIGHT/TNFSF14 Protein in solution form, produced by Sf9 insect cells, with N-terminal His-tag.
Cat. No. Product Name Effect Purity