526-08-9
526-08-9
Chemical Structure
Sulfaphenazole
- CAS No.: 526-08-9
- Formula:C15H14N4O2S
- Molecular Weight:314.36
IUPAC Name: 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
InChIKey: QWCJHSGMANYXCW-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N)C=C1)(NC2=CC=NN2C3=CC=CC=C3)=O
Biological Activity: Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sulfaphenazole | 99.85% | Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion. | ||||||||||||||||||||
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Sulfaphenazole (Standard) | 99.82% | Sulfaphenazole (Standard) is the analytical standard of Sulfaphenazole. This product is intended for research and analytical applications. Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion. | ||||||||||||||||||||
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Sulfaphenazole-d4 | 99.66% | Sulfaphenazole-d4 is the deuterium labeled Sulfaphenazole (HY-B1218). Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion. | ||||||||||||||||||||
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Sulfamethylphenazole sodium | Sulfamethylphenazole sodium (Sulfapyrazole sodium; Vesulong sodium) is a long-acting sulfonamide antibacterial agent. Sulfamethylphenazole sodium maintains effective chemotherapeutic blood concentrations through the slow release of free sulfonamide from a protein-binding reservoir and can be used in combination with antibiotics such as Terramycin for bovine hemorrhagic septicemia. Sulfamethylphenazole sodium exhibits moderate antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MIC = 15.38 μg/mL) and inhibitory activity against CYP 2C9. Sulfamethylphenazole sodium can be used in studies related to tuberculosis and hemorrhagic septicemia. | |||||||||||||||||||||
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Sulfamethylphenazole potassium | Sulfamethylphenazole potassium (Sulfapyrazole potassium; Vesulong potassium) is a long-acting sulfonamide antibacterial agent. Sulfamethylphenazole potassium maintains effective chemotherapeutic blood concentrations through the slow release of free sulfonamide from a protein-binding reservoir and can be used in combination with antibiotics such as Terramycin for bovine hemorrhagic septicemia. Sulfamethylphenazole potassium exhibits moderate antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MIC = 15.38 μg/mL) and inhibitory activity against CYP 2C9. Sulfamethylphenazole potassium can be used in studies related to tuberculosis and hemorrhagic septicemia. | |||||||||||||||||||||
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C-7280948 | 99.91% | C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC50 value of 12.75 μM. | ||||||||||||||||||||
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β-catenin-IN-8 | β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt-target genes level (Fgf20 and Sall4). β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability. | |||||||||||||||||||||
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Sulfapyridine (Standard) | 99.86% | Sulfapyridine (Standard) is the analytical standard of Sulfapyridine. This product is intended for research and analytical applications. Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities. | ||||||||||||||||||||
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Sulfaquinoxaline (Standard) | ≥98% | Sulfaquinoxaline (Standard) is the analytical standard of Sulfaquinoxaline. This product is intended for research and analytical applications. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections. | ||||||||||||||||||||
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Sulfachloropyridazine (Standard) | 98.32% | Sulfachloropyridazine (Standard) is the analytical standard of Sulfachloropyridazine. This product is intended for research and analytical applications. Sulfachloropyridazine is a broad spectrum sulfonamide that can be used against both gram-positive and gram-negative aerobic bacteria as well as Chlamydia. Sulfachloropyridazine is also considered as a common pollutant in surface and groundwater. Sulfachloropyridazine via electro-Fenton is a model for sulfonamide antibiotics that are widespread in waters. | ||||||||||||||||||||
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Sulfachloropyridazine-13C6 | Sulfachloropyridazine-13C6 is the 13C6 labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria. | |||||||||||||||||||||
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Sulfabenz | Sulfabenz (Compound 9) is an amine-substituted N1-phenylsulfonyl indole derivative. Sulfabenz has binding activity to human 5-HT6 serotonin receptor (Ki: 200 nM). Sulfabenz can be used to study the ligand binding mechanism of 5-HT6 receptor and 5-HT6 receptor-related neurological diseases. | |||||||||||||||||||||
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References
- [1]. Qing Chang, et al. Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors. J Biol Chem. 2014 Mar 21;289(12):8337-52. [Content Brief]
- [2]. Shahrzad Elmi, et al. Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice. Vascul Pharmacol. 2008 Jan;48(1):1-8. [Content Brief]
- [3]. Christopher T Turner, et al. Sulfaphenazole reduces thermal and pressure injury severity through rapid restoration of tissue perfusion. Sci Rep. 2022 Jul 23;12(1):12622. [Content Brief]
