2. Others Apoptosis Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Antibiotic Necroptosis Apoptosis Isotope-Labeled Compounds Cytochrome P450
  4. Sulfaphenazole-d4

Sulfaphenazole-d4 is the deuterium labeled Sulfaphenazole (HY-B1218). Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion.

For research use only. We do not sell to patients.

Sulfaphenazole-d<sub>4</sub>

Sulfaphenazole-d4 Chemical Structure

CAS No. : 2702538-04-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Solid
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Based on 1 publication(s) in Google Scholar

Other Forms of Sulfaphenazole-d4:

Sulfaphenazole-d4 Related Antibodies

Top Publications Citing Use of Products

View All Antibiotic Isoform Specific Products:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

Sulfaphenazole-d4 is the deuterium labeled Sulfaphenazole (HY-B1218). Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion[1][2][3].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfaphenazole-d4 Related Antibodies
Molecular Weight

318.39

Formula

C15H10D4N4O2S
CAS No.
Unlabeled CAS
Appearance

Solid

SMILES

O=S(C1=C([2H])C([2H])=C(N)C([2H])=C1[2H])(NC2=CC=NN2C3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (157.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1408 mL 15.7040 mL 31.4080 mL
5 mM 0.6282 mL 3.1408 mL 6.2816 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1408 mL 15.7040 mL 31.4080 mL 78.5201 mL
5 mM 0.6282 mL 3.1408 mL 6.2816 mL 15.7040 mL
10 mM 0.3141 mL 1.5704 mL 3.1408 mL 7.8520 mL
15 mM 0.2094 mL 1.0469 mL 2.0939 mL 5.2347 mL
20 mM 0.1570 mL 0.7852 mL 1.5704 mL 3.9260 mL
25 mM 0.1256 mL 0.6282 mL 1.2563 mL 3.1408 mL
30 mM 0.1047 mL 0.5235 mL 1.0469 mL 2.6173 mL
40 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9630 mL
50 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5704 mL
60 mM 0.0523 mL 0.2617 mL 0.5235 mL 1.3087 mL
80 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
100 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
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Sulfaphenazole-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfaphenazole-d42702538-04-1BacterialAntibioticNecroptosisApoptosisIsotope-Labeled CompoundsCytochrome P450CYPsInhibitorinhibitorinhibit

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