Sulfamethylphenazole sodium
Sulfamethylphenazole (Sulfapyrazole; Vesulong) sodium is a long-acting sulfonamide antibacterial agent. Sulfamethylphenazole sodium maintains effective blood concentrations for chemotherapy via slow release of free sulfonamides from protein-binding reservoirs. Sulfamethylphenazole sodium can be used in combination with antibiotics such as terramycin for the treatment of hemorrhagic septicemia in cattle. Sulfamethylphenazole sodium is applicable to research related to hemorrhagic septicemia.
For research use only. We do not sell to patients.
- CAS No.: 18179-65-2
- Formula: C16H16N4NaO2S
- Molecular Weight:351.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sulfamethylphenazole sodium, when used in combination with terramycin, is preferred by 60% of veterinarians, while its single-agent use is accepted by 30% of them, in field surveys of hemorrhagic septicemia in cattle/buffaloes in Punjab, Pakistan. Moreover, it is only effective when administered in the early stage of the disease[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female calves (Kalbinnen), 2-3 years of age[1]
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Dosage:10 mL/100 kg; 20 mL/100 kg; 30 mL/100 kg
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Administration:i.m.; single injection
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Result:10 mL/100 kg dose group: twenty-four hours after dosing, the mean total sulfonamide in whole blood was 0.8 mg/100 mL and the mean free sulfonamide was 0.1 mg/100 mL. This free level was below the chemotherapeutically active threshold (0.2-0.3 mg/100 mL whole blood) and did not maintain an effective blood concentration.
20 mL/100 kg dose group: twenty-four hours after dosing, the mean total sulfonamide in whole blood was 2.1 mg/100 mL and the mean free sulfonamide was 0.3 mg/100 mL. This free level reached the active threshold and sustained a chemotherapeutically effective concentration for at least 24 hours.
30 mL/100 kg dose group: twenty-four hours after dosing, the mean total sulfonamide in whole blood was 4.2 mg/100 mL and the mean free sulfonamide was 0.7 mg/100 mL. This exceeded the active threshold and represented supratherapeutic exposure.
A single intramuscular injection of 20 mL of the 20% test sulfonamide solution per 100 kg body weight was the optimal dosage to maintain a chemotherapeutically active free sulfonamide level for at least 24 hours in cattle.
Chemical Information
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CAS No. 18179-65-2
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Molecular Weight 351.38
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Formula C16H16N4NaO2S
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SMILES
O=S(NC1=CC(C)=NN1C2=CC=CC=C2)(C3=CC=C(C=C3)N)=O.[Na]
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Synonyms
Sulfapyrazole sodium; Vesulong sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Sheikh MA, et al. Observations on haemorrhagic septicaemia in Pakistan livestock. Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B. 1996 Jul;43(5):293-304. [Content Brief]
[3]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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