1. Epigenetics
  2. Histone Methyltransferase
  3. C-7280948

C-7280948 

Cat. No.: HY-15890 Purity: 98.31%
Handling Instructions

C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC50 value of 12.75 μM.

For research use only. We do not sell to patients.

C-7280948 Chemical Structure

C-7280948 Chemical Structure

CAS No. : 587850-67-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 252 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC50 value of 12.75 μM[1].

IC50 & Target

IC50: 12.75 μM (PRMT1)[1]

In Vitro

C-7280948 is compound 6a in this article, it against hPRMT1 with an IC50 value of 12.75 μM.
Especially arginine methyltransferases also target non-histone protein substrates and are therefore often called protein methyltransferases (PRMTs).
The subtype PRMT1 has been linked to the activation of estrogen and androgen receptors and therefore may represent a new treatment option for hormone-dependent cancer.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.35

Formula

C₁₄H₁₆N₂O₂S

CAS No.

587850-67-7

SMILES

O=S(C1=CC=C(N)C=C1)(NCCC2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 38 mg/mL (137.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6186 mL 18.0930 mL 36.1860 mL
5 mM 0.7237 mL 3.6186 mL 7.2372 mL
10 mM 0.3619 mL 1.8093 mL 3.6186 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

C-7280948C7280948C 7280948Histone MethyltransferaseCancerhPRMT1proteinmethyltransferasehormoneInhibitorinhibitorinhibit

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Product Name:
C-7280948
Cat. No.:
HY-15890
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