50865-01-5
50865-01-5
Chemical Structure
Protoporphyrin IX disodium
Synonym(s): PPIX disodium
- CAS No.: 50865-01-5
- Formula:C34H32N4Na2O4
- Molecular Weight:606.62
IUPAC Name: sodium 3,3'-(3,8,13,17-tetramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionate
InChIKey: VWIKDHUBYGYUKW-HXFTUNQESA-L
SMILES: O=C(O[Na])CCC1=C2/C=C3C(CCC(O[Na])=O)=C(C)C(/C=C(N/4)/C(C)=C(C=C)C4=C\C5=N/C(C(C=C)=C5C)=C\C(N2)=C1C)=N/3
Biological Activity: Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Protoporphyrin IX disodium | 96.5% | Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma. | ||||||||||||||||||||
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Coproporphyrin III | 99.57% | Coproporphyrin III (Zincphyrin) is a naturally occurring porphyrin derivative that is mainly found in urine. | ||||||||||||||||||||
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Coproporphyrin I | 99.68% | Coproporphyrin I is an endogenous metabolite present in Urine and Blood that can be used for the research of Liver Disease and Porphyria. | ||||||||||||||||||||
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N-Methylprotoporphyrin IX | 99.0% | N-Methylprotoporphyrin IX is a Ferrochelatase inhibitor with a Kiapp value of 3 nM. N-methylprotoporphyrin IX dimethyl ester potently inhibits the synthesis of phycocyanin and chlorophyll a. N-Methylprotoporphyrin IX can be used for the research of haem deficiency-associated disorders. | ||||||||||||||||||||
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Protoporphyrin IX | 98.0% | Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma. | ||||||||||||||||||||
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Hematin | 95.08% | Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins. Hematin can be used for the research of acute porphyrias and cancer. | ||||||||||||||||||||
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Mesoporphyrin dimethyl ester | Mesoporphyrin dimethyl ester (Mesoporphyrin IX dimethyl ester) is a biochemical reagent. | |||||||||||||||||||||
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Pyroporphyrin dimethyl ester | Deuteroporphyrin dimethyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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Coproporphyrin I tetramethyl ester | Coproporphyrin I tetramethyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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Mesoporphyrin IX dihydrochloride | 95.90% | Mesoporphyrin IX (dihydrochloride) is a photosensitizer that can be used to modify liposomes. Mesoporphyrin IX (dihydrochloride) can insert into lipid vesicles and disrupt the viral membrane structure in vesicular stomatitis virus (VSV), inducing cross-linking of VSV glycoproteins, thereby inhibiting viral activity. |
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Hematoporphyrin IX dimethyl ester | Hematoporphyrin IX dimethyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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References
- [1]. Yasushi Nakai, et al.Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.
- [2]. Myrzakhmetov B, et al. Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a and Photofrin® in Different Conditions. Pharmaceuticals (Basel). 2021 Feb 9;14(2):138. [Content Brief]
- [3]. Tope WD, et al. Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid[J]. Photochem Photobiol. 1998 Feb;67(2):249-55. [Content Brief]
- [4]. van den Boogert J, et al. 5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration[J]. J Photochem Photobiol B. 1998 Jun 15;44(1):29-38. [Content Brief]
- [5]. Li C, et al. G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes. Genome Biol. 2022 Dec 15;23(1):259. [Content Brief]
