5451-09-2
Chemical Structure
5-Aminolevulinic acid hydrochloride
Synonym(s): 5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride
- CAS. Nr.: 5451-09-2
- Formula:C5H10ClNO3
- Molecular Weight:167.59
IUPAC Name: 5-amino-4-oxopentanoic acid hydrochloride
InChIKey: ZLHFONARZHCSET-UHFFFAOYSA-N
SMILES: O=C(O)CCC(CN)=O.[H]Cl
Biological Activity: 5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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5-Aminolevulinic acid hydrochloride | 99.61% | 5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy. | ||||||||||||||||||||
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5-Aminolevulinic acid hydrochloride (Standard) | 99.85% | 5-Aminolevulinic acid (hydrochloride) (Standard) is the analytical standard of 5-Aminolevulinic acid (hydrochloride). This product is intended for research and analytical applications. 0 | ||||||||||||||||||||
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5-Aminolevulinic acid-13C-1 hydrochloride | 98.0% | 5-Aminolevulinic acid-13C-1 (5-ALA-13C-1) hydrochloride is the 13C labeled 5-Aminolevulinic acid hydrochloride. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. | ||||||||||||||||||||
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5-Aminolevulinic acid-15N hydrochloride | 5-Aminolevulinic acid-15N (hydrochloride) is the 15N-labeled 5-Aminolevulinic acid (hydrochloride). 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. | |||||||||||||||||||||
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5-Aminolevulinic acid-13C hydrochloride | 98% | 5-Aminolevulinic acid-13C (hydrochloride) is the 13C labeled 5-Aminolevulinic acid hydrochloride. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. | ||||||||||||||||||||
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5-Aminolevulinic acid-d2 hydrochloride | 91.20% | 5-Aminolevulinic acid-d2 (hydrochloride) is deuterium labeled 5-Aminolevulinic acid (hydrochloride). | ||||||||||||||||||||
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- [1]. Ogura S, et al. The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver. BMC Res Notes. 2011;4:66. Published 2011 Mar 17. [Content Brief]
- [2]. Saitoh S, et al. 5-Aminolevulinic Acid (5-ALA) Plays an Important Role in the Function of Innate Immune Cells. Inflammation. 2025;48(4):2588-2599. [Content Brief]
- [3]. Takahashi J, et al. 5-Aminolevulinic acid enhances cancer radiotherapy in a mouse tumor model. Springerplus. 2013;2:602. Published 2013 Nov 12. [Content Brief]
