5-Aminolevulinic acid-d2 hydrochloride
Based on 1 Customer Validation
5-Aminolevulinic acid-d2 (hydrochloride) is deuterium labeled 5-Aminolevulinic acid (hydrochloride).
For research use only. We do not sell to patients.
- Purity: 91.20%
- CAS No.: 187237-35-0
- Formula: C5H8D2ClNO3
- Molecular Weight:169.60
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 187237-35-0
-
Unlabeled CAS 5451-09-2
-
Appearance Solid
-
Molecular Weight 169.60
-
Formula C5H8D2ClNO3
-
Color Off-white to light yellow
-
SMILES
OC(C([2H])([2H])CC(CN)=O)=O.Cl
-
Synonyms
5-ALA-d2 hydrochloride; δ-Aminolevulinic acid-d2 hydrochloride; 5-Amino-4-oxopentanoic acid-d2 hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 12.5 mg/mL (73.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401. [Content Brief]
[3]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.8962 mL | 29.4811 mL | 58.9623 mL | 147.4057 mL |
| 5 mM | 1.1792 mL | 5.8962 mL | 11.7925 mL | 29.4811 mL | |
| 10 mM | 0.5896 mL | 2.9481 mL | 5.8962 mL | 14.7406 mL | |
| 15 mM | 0.3931 mL | 1.9654 mL | 3.9308 mL | 9.8270 mL | |
| 20 mM | 0.2948 mL | 1.4741 mL | 2.9481 mL | 7.3703 mL | |
| 25 mM | 0.2358 mL | 1.1792 mL | 2.3585 mL | 5.8962 mL | |
| 30 mM | 0.1965 mL | 0.9827 mL | 1.9654 mL | 4.9135 mL | |
| 40 mM | 0.1474 mL | 0.7370 mL | 1.4741 mL | 3.6851 mL | |
| 50 mM | 0.1179 mL | 0.5896 mL | 1.1792 mL | 2.9481 mL | |
| 60 mM | 0.0983 mL | 0.4914 mL | 0.9827 mL | 2.4568 mL |
5-Aminolevulinic acid-d2 hydrochloride Related Classifications
HY-N0305S1 Related Classifications
Powered by Bioz