1. Autophagy
    Apoptosis
    Metabolic Enzyme/Protease
  2. Autophagy
    Mitophagy
    Endogenous Metabolite
    Apoptosis
  3. 5-Aminolevulinic acid hydrochloride

5-Aminolevulinic acid hydrochloride (Synonyms: ALA; 5-ALA)

Cat. No.: HY-N0305 Purity: >98.0%
Handling Instructions

5-Aminolevulinic acid hydrochloride (ALA) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.

For research use only. We do not sell to patients.

5-Aminolevulinic acid hydrochloride Chemical Structure

5-Aminolevulinic acid hydrochloride Chemical Structure

CAS No. : 5451-09-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 78 In-stock
Estimated Time of Arrival: December 31
5 g USD 198 In-stock
Estimated Time of Arrival: December 31
10 g USD 300 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

5-Aminolevulinic acid hydrochloride (ALA) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

5-Aminolevulinic acid hydrochloride (ALA) is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique[2] .

Clinical Trial
Molecular Weight

167.59

Formula

C₅H₁₀ClNO₃

CAS No.

5451-09-2

SMILES

O=C(O)CCC(CN)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (895.04 mM)

H2O : ≥ 50 mg/mL (298.35 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9669 mL 29.8347 mL 59.6694 mL
5 mM 1.1934 mL 5.9669 mL 11.9339 mL
10 mM 0.5967 mL 2.9835 mL 5.9669 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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KeyWords:

5-Aminolevulinic acid | ALA | 5-ALA | Autophagy | Mitophagy | Endogenous Metabolite | Apoptosis | Mitochondrial Autophagy | Inhibitor | inhibitor | inhibit

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Product name:
5-Aminolevulinic acid hydrochloride
Cat. No.:
HY-N0305
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