γ-Aminobutyric acid-d2
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γ-Aminobutyric acid-d2 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
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- Pureté: 99.95%
- CAS No.: 67910-98-9
- Formule: C4H7D2NO2
- Masse moléculaire:105.13
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 67910-98-9
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Unlabeled Cas 56-12-2
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Appearance Solid
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Masse moléculaire 105.13
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Formule C4H7D2NO2
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Color White to off-white
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SMILES
[2H]C(CCN)([2H])C(O)=O
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Synonyms
4-Aminobutyric acid-d2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
H2O : ≥ 50 mg/mL (475.60 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2. [Content Brief]
[3]. Okada R, et al. Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514(1):74-91. [Content Brief]
[4]. Watanabe M, et al. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol. 2002;213:1-47. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.5120 mL | 47.5602 mL | 95.1203 mL | 237.8008 mL |
| 5 mM | 1.9024 mL | 9.5120 mL | 19.0241 mL | 47.5602 mL | |
| 10 mM | 0.9512 mL | 4.7560 mL | 9.5120 mL | 23.7801 mL | |
| 15 mM | 0.6341 mL | 3.1707 mL | 6.3414 mL | 15.8534 mL | |
| 20 mM | 0.4756 mL | 2.3780 mL | 4.7560 mL | 11.8900 mL | |
| 25 mM | 0.3805 mL | 1.9024 mL | 3.8048 mL | 9.5120 mL | |
| 30 mM | 0.3171 mL | 1.5853 mL | 3.1707 mL | 7.9267 mL | |
| 40 mM | 0.2378 mL | 1.1890 mL | 2.3780 mL | 5.9450 mL | |
| 50 mM | 0.1902 mL | 0.9512 mL | 1.9024 mL | 4.7560 mL | |
| 60 mM | 0.1585 mL | 0.7927 mL | 1.5853 mL | 3.9633 mL | |
| 80 mM | 0.1189 mL | 0.5945 mL | 1.1890 mL | 2.9725 mL | |
| 100 mM | 0.0951 mL | 0.4756 mL | 0.9512 mL | 2.3780 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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