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製品番号: HY-184113

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Dihydropelitinib

Name: Dihydropelitinib
Brand: MedChemExpress
SKU: HY-184113
Availability: PreOrder

(別名: DHP)

Dihydropelitinib (DHP) is a ILK ligand with a K_d value of 252 nM. Dihydropelitinib acts as a cytoskeleton modulator that induces actin (Actin) cytoskeleton rearrangement. Dihydropelitinib exhibits anticancer activity against liver cancer and lung adenocarcinoma. Dihydropelitinib can be used in studies related to liver cancer and lung adenocarcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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分子式: C₂₄H₂₅ClFN₅O₂
分子量:469.94

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dihydropelitinib 構造式

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Integrin アイソフォーム固有の製品をすべて表示 :

体外実験

Dihydropelitinib (0.019-2.500 μM) binds specifically to the ILK:α-parvin complex, with an equilibrium dissociation constant (K_d) of 252 nM^[1].
Dihydropelitinib (serial dilution; 2 h treatment) binds to full-length ILK in digitonin (HY-N4000)-permeabilized HEK293T cells, with an IC₅₀ of 980 nM as determined by NanoBRET target binding assay^[1].
Dihydropelitinib (0.22-2.50 μM; 48 h) induces concentration-dependent rearrangement of the actin cytoskeleton in hepatocellular carcinoma Huh-7 cells after 48 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 469.94
分子式 C₂₄H₂₅ClFN₅O₂
SMILES

FC(C=CC(NC1=C(C=NC2=CC(OCC)=C(NC(CCCN(C)C)=O)C=C12)C#N)=C3)=C3Cl
別名

DHP
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Greco FA, et al. Identification and Validation of 3-Cyano-Quinoline Ligands Targeting Integrin-Linked Kinase (ILK). J Med Chem. 2026 Jun 11;69(11):12982-13001. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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